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Comparison of the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low-grade and high-grade squamous intraepithelial lesions across different age groups
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Abstract
Objectives: To assess the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low grade and high-grade squamous intraepithelial lesions across different age groups.
Material and methods: The study included 1103 patients, age 25–70 years. All patients underwent in-depth diagnostic tests following either an abnormal Pap test result or a clinically suspicious cervical lesion. In all women the following examinations were performed: a molecular test detecting 14 high-risk types of HPV, a colposcopy examination, as well as directed-biopsy of the cervix. The studied population was subdivided into four age groups.
Results: It was observed that the percentage of high grade squamous intraepithelial lesions (HSIL) and cancers increased with women’s age. Sensitivity of both methods for detecting high-grade squamous intraepithelial lesions was highest for women aged 40–49 years. Sensitivity values of HPV testing was higher than that of cervical cytology among women under age 50.
Conclusions: Specificity of HPV testing increased significantly with age of women and was several fold higher across all age groups than the specificity of cervical cytology.
Abstract
Objectives: To assess the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low grade and high-grade squamous intraepithelial lesions across different age groups.
Material and methods: The study included 1103 patients, age 25–70 years. All patients underwent in-depth diagnostic tests following either an abnormal Pap test result or a clinically suspicious cervical lesion. In all women the following examinations were performed: a molecular test detecting 14 high-risk types of HPV, a colposcopy examination, as well as directed-biopsy of the cervix. The studied population was subdivided into four age groups.
Results: It was observed that the percentage of high grade squamous intraepithelial lesions (HSIL) and cancers increased with women’s age. Sensitivity of both methods for detecting high-grade squamous intraepithelial lesions was highest for women aged 40–49 years. Sensitivity values of HPV testing was higher than that of cervical cytology among women under age 50.
Conclusions: Specificity of HPV testing increased significantly with age of women and was several fold higher across all age groups than the specificity of cervical cytology.
Keywords
Pap test, HPV testing, low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), age groups
About this articleTitle
Comparison of the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low-grade and high-grade squamous intraepithelial lesions across different age groups
Journal
Issue
Article type
Research paper
Pages
141-146
Published online
2017-03-31
Page views
1931
Article views/downloads
2207
DOI
Pubmed
Bibliographic record
Ginekol Pol 2017;88(3):141-146.
Keywords
Pap test
HPV testing
low-grade squamous intraepithelial lesions (LSIL)
high-grade squamous intraepithelial lesions (HSIL)
age groups
Authors
Aleksandra Paluszkiewicz
Dominik Pruski
Kinga Iwaniec
Witold Kędzia
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