open access
Does the patients age at cancer diagnosis affect microvessels density in uterine sarcoma tissues?
open access
Abstract
Objectives: The objective of the study was to retrospectively evaluate the density of vessels exhibiting positive glycoprotein CD34 expression in the uterine leiomyosarcoma tissues and their correlation with the age of patients at the time of tumor diagnosis.
Material and methods: The archival paraffin blocks with the cancer tissues collected from 50 patients suffering from uterine leiomyosarcoma were used together with their clinical and demographic data. The immunohistochemical peroxidase-dependent methods were used to detect microvessels with positive CD34 expression. The glycoprotein CD34 expression was evaluated as a density of microvessel showing the positive immunohistochemical reaction (MVDCD34).
Results: The negative, statistically significant correlation between the age of patients (at the moment diagnosis) and the MVDCD34+ (R = –0.289, p = 0.042) was found.
Conclusions: The study’s findings may suggest that the tissues of younger people constitute a permissive environment for pro-angiogenic factors.
Abstract
Objectives: The objective of the study was to retrospectively evaluate the density of vessels exhibiting positive glycoprotein CD34 expression in the uterine leiomyosarcoma tissues and their correlation with the age of patients at the time of tumor diagnosis.
Material and methods: The archival paraffin blocks with the cancer tissues collected from 50 patients suffering from uterine leiomyosarcoma were used together with their clinical and demographic data. The immunohistochemical peroxidase-dependent methods were used to detect microvessels with positive CD34 expression. The glycoprotein CD34 expression was evaluated as a density of microvessel showing the positive immunohistochemical reaction (MVDCD34).
Results: The negative, statistically significant correlation between the age of patients (at the moment diagnosis) and the MVDCD34+ (R = –0.289, p = 0.042) was found.
Conclusions: The study’s findings may suggest that the tissues of younger people constitute a permissive environment for pro-angiogenic factors.
Keywords
microvessels density, uterine sarcoma, patient age
About this articleTitle
Does the patients age at cancer diagnosis affect microvessels density in uterine sarcoma tissues?
Journal
Issue
Article type
Research paper
Pages
138-140
Published online
2017-03-31
Page views
1244
Article views/downloads
1435
DOI
Pubmed
Bibliographic record
Ginekol Pol 2017;88(3):138-140.
Keywords
microvessels density
uterine sarcoma
patient age
Authors
Marcin Bobiński
Wiesława Bednarek
Karolina Okła
Grzegorz Polak
Małgorzata Sobstyl
Iwona Wertel
Jan Kotarski
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