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Perinatal factors affecting the gut microbiota — are they preventable?
, 2, 1, 3
Affiliations- Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland
- Department of Human Nutrition and Metabolomics, Szczecin, Poland
- Department of Neonatology, Medical University in Szczecin, Poland, Poland
open access
Abstract
Intestinal microbiota affects many aspects of physiological processes. The type of microbiota in the early stages of life is
a critical element conditioning the development of the immune response and food tolerance. Disturbed colonization of
the digestive tract resulting from the amount or diversity of bacteria colonies stimulates an inflammatory response that
is associated in later life with inflammatory and autoimmune diseases. One of the elements disturbing normal colonization
in the perinatal period is the operative way of delivery by caesarean section and the administration of antibiotics,
used as a prophylactic measure as well as for therapeutic reasons. Based on the current state of knowledge, there is a lot
of evidence demonstrating the long-term adverse effects of these modifying agents for gut microbiota, which should be
kept to a minimum as far as possible.
Abstract
Intestinal microbiota affects many aspects of physiological processes. The type of microbiota in the early stages of life is
a critical element conditioning the development of the immune response and food tolerance. Disturbed colonization of
the digestive tract resulting from the amount or diversity of bacteria colonies stimulates an inflammatory response that
is associated in later life with inflammatory and autoimmune diseases. One of the elements disturbing normal colonization
in the perinatal period is the operative way of delivery by caesarean section and the administration of antibiotics,
used as a prophylactic measure as well as for therapeutic reasons. Based on the current state of knowledge, there is a lot
of evidence demonstrating the long-term adverse effects of these modifying agents for gut microbiota, which should be
kept to a minimum as far as possible.
Keywords
gut microbiota; neonate; antibiotics; cesarean section
About this articleTitle
Perinatal factors affecting the gut microbiota — are they preventable?
Journal
Issue
Article type
Review paper
Pages
709-713
Published online
2020-11-30
Page views
837
Article views/downloads
966
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(11):709-713.
Keywords
gut microbiota
neonate
antibiotics
cesarean section
Authors
Maciej Zietek
Malgorzata Szczuko
Zbigniew Celewicz
Agnieszka Kordek
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