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Retrospective analysis of the diagnostic effectiveness of the sentinel lymph node biopsy (SLNB) in vulvar cancer
, 2, 3, 4, 1
Affiliations- Department of Gynecologic Oncology, Maria Sklodowska-Curie National Research Institute of Oncology Warsaw, Poland
- Department of Biostatistics, Maria Sklodowska-Curie National Research Institute of Oncology Warsaw, Poland
- Department of Endocrinology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology Warsaw, Poland
- 2-nd Clinic of Obstetrics and Gynecology, Medical University of Warsaw, Poland
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Abstract
Objectives: Inguinal lymphadenectomy used in the treatment of vulvar cancer often results in complications, such as
lymphoedema or abnormal wound healing. Aim of this study was assessment of the diagnostic effectiveness of the sentinel
lymph node biopsy (SLNB) procedure in patients treated due to vulvar cancer.
Material and methods: Eighty-four patients diagnosed with squamous cell vulvar carcinoma (FIGO I-IV) underwent
preoperative lymphoscintigraphy with technetium 99 to map sentinel lymph node. During surgery sentinel lymph nodes
were identified and resected, followed by complete bilateral groin lymphadenectomy.
Results: Sentinel lymph nodes were mapped with lymphoscintigraphy and biopsied in 84.3% and 90.1% of patients, respectively.
False negative predictive value (FNPV) was 9.1% and false negative rate (FNR) was recorded in 16.7% of cases. Patients
in advanced stages (FIGO III and IV) had significantly lower rate of lymphatic mapping compared to those in stage I and II
(OR = 0.148, p = 0.022). Detection of sentinel lymph node in lymphoscintigraphy for tumor grade 2 and 3 was nearly eight
times lower than for grade 1 cancers, however without statistical significance (OR = 0.126, p = 0.058).
Conclusions: The use of SLNB should be limited to vulvar cancer patients in early clinical stages.
Abstract
Objectives: Inguinal lymphadenectomy used in the treatment of vulvar cancer often results in complications, such as
lymphoedema or abnormal wound healing. Aim of this study was assessment of the diagnostic effectiveness of the sentinel
lymph node biopsy (SLNB) procedure in patients treated due to vulvar cancer.
Material and methods: Eighty-four patients diagnosed with squamous cell vulvar carcinoma (FIGO I-IV) underwent
preoperative lymphoscintigraphy with technetium 99 to map sentinel lymph node. During surgery sentinel lymph nodes
were identified and resected, followed by complete bilateral groin lymphadenectomy.
Results: Sentinel lymph nodes were mapped with lymphoscintigraphy and biopsied in 84.3% and 90.1% of patients, respectively.
False negative predictive value (FNPV) was 9.1% and false negative rate (FNR) was recorded in 16.7% of cases. Patients
in advanced stages (FIGO III and IV) had significantly lower rate of lymphatic mapping compared to those in stage I and II
(OR = 0.148, p = 0.022). Detection of sentinel lymph node in lymphoscintigraphy for tumor grade 2 and 3 was nearly eight
times lower than for grade 1 cancers, however without statistical significance (OR = 0.126, p = 0.058).
Conclusions: The use of SLNB should be limited to vulvar cancer patients in early clinical stages.
Keywords
sentinel lymph node procedure; vulvar cancer; retrospective analysis
About this articleTitle
Retrospective analysis of the diagnostic effectiveness of the sentinel lymph node biopsy (SLNB) in vulvar cancer
Journal
Issue
Article type
Research paper
Pages
379-382
Published online
2020-07-31
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873
Article views/downloads
840
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(7):379-382.
Keywords
sentinel lymph node procedure
vulvar cancer
retrospective analysis
Authors
Szymon Piatek
Wojciech Michalski
Malgorzata Benke
Anna Danska-Bidzinska
Mariusz Bidzinski
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