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Circulating omentin-1 levels and inflammation in polycystic ovary syndrome
Affiliations- Department of Endocrinological Gynecology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice
- Women's Health Chair, School of Health Science, Medical University of Silesia, Poland
- Department of Statistics, Department of Instrumental Analysis, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia Katowice
- Chair of Physiotherapy, School of Health Science, Medical University of Silesia,
- Pathophysiology Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland 6 Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland
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Abstract
Objectives: The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status and
inflammation in PCOS.
Material and methods: A cross-sectional study involving 86 PCOS (47 obese) and 72 Non-PCOS women (41 obese) determined
anthropometric parameters and body composition. Serum glucose, insulin and omentin-1, TNF-α, sTNFRs, IL-6 and
sR-IL6 were measured in the fasting state.
Results: Plasma omentin-1 levels were significantly lower in the PCOS than in the Non-PCOS group and both corresponding
normal weight and obese subgroups. In three analyzed least-angle regression (LARS) models the lower plasma omentin-
1 levels was associated with PCOS occurrence, higher circulating TNF-α and lower IL-6 levels.
Conclusions: Suppressed omentin-1 levels in PCOS are characteristic for this disturbance and proinflammatory cytokines
are factors modifying secretion of this adipokine.
Abstract
Objectives: The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status and
inflammation in PCOS.
Material and methods: A cross-sectional study involving 86 PCOS (47 obese) and 72 Non-PCOS women (41 obese) determined
anthropometric parameters and body composition. Serum glucose, insulin and omentin-1, TNF-α, sTNFRs, IL-6 and
sR-IL6 were measured in the fasting state.
Results: Plasma omentin-1 levels were significantly lower in the PCOS than in the Non-PCOS group and both corresponding
normal weight and obese subgroups. In three analyzed least-angle regression (LARS) models the lower plasma omentin-
1 levels was associated with PCOS occurrence, higher circulating TNF-α and lower IL-6 levels.
Conclusions: Suppressed omentin-1 levels in PCOS are characteristic for this disturbance and proinflammatory cytokines
are factors modifying secretion of this adipokine.
Keywords
omentin-1; inflammation; nutritional status; PCOS
About this articleTitle
Circulating omentin-1 levels and inflammation in polycystic ovary syndrome
Journal
Issue
Article type
Research paper
Pages
308-312
Published online
2020-06-30
Page views
1767
Article views/downloads
1431
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(6):308-312.
Keywords
omentin-1
inflammation
nutritional status
PCOS
Authors
Grzegorz Franik
Marcin Sadlocha
Pawel Madej
Aleksander Owczarek
Violetta Skrzypulec-Plinta
Ryszard Plinta
Jerzy Chudek
Magdalena Olszanecka-Glinianowicz
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