Nasal bone in screening for Trisomy 18 and 13 at 11–13 + 6 weeks of gestation — own experiences
Abstract
Objectives: The objective of the paper is the suitability assessment of screening for Trisomy 18 and 13 on the basis of NT
measurement, FHR, double test and assessment of Nasal Bone.
Material and methods: The study was performed in 6,661 singleton pregnancies. In each fetus NT, FHR, DV-PIV were
examined. Double test from maternal blood was examined. These ultrasound and biochemical factors were in combined
screening investigated. Additional ultrasound marker — Nasal Bone was and its impact on Trisomies 18 and 13 screening
was examined.
Results: Two groups of patients were compared — with chromosomal normal and chromosomal abnormalities — Trisomy
18 and 13. Detection Rate of Trisomies 18 and 13 at the risk cutoff 1/300 using combined screening was 84.1% and FPR
was 7.1%. Detection Rates of examined chromosomal abnormalities using screening with additional marker — NB was
93.2% and False Positive Rate — 5.6%.
Conclusions: It should be noted that the qualitative analysis of the assessment of NB in the first trimester significantly
influences the improvement of screening values focusing on Trisomy 18 and 13 detection. In summary, our research indicates
a more effective type of Trisomy 13 and 18 screening using NT, double test, maternal age, CRL and FHR as well as
nasal bone presence and absence.
Keywords: combined test Trisomy 18 Trisomy 13first trimester nuchal translucency thicknessNasal BoneSerum free β-hCGPregnancy-associated plasma protein A
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