open access
Smoking reduces ovarian stromal blood flow in polycystic ovary syndrome patients
, 1
Affiliations- Department of Obstetrics and Gynecology, Faculty of Medicine, Near East University, Nicosia, Cyprus
open access
Abstract
Objectives: The objective of the current research is to compare hormonal, metabolic and ovarian stromal blood flow
outcomes in smoking versus non-smoking polycystic ovary syndrome (PCOS) patients.
Material and methods: 79 PCOS women (Group 1) and 79 healthy subjects (Group 2) were recruited. Both groups were
subdivided according to their smoking habits. Ovarian stromal blood flow was assessed with pulsatility and resistance
index for both ovaries and compared among smoking women.
Results: The smokers in the PCOS group had statistically significant higher levels of pulsatility and resistance index in both
ovaries compared to nonsmoker PCOS patients (p < 0.001). Comparison of ovarian stromal blood flow indexes shows that
pulsatility and resistance index for both ovaries is statistically significantly high in smoking healthy patients compared to
the nonsmoking group (p < 0.001). There is a positive correlation between smoking and free androgen index (r = 0.866,
p < 0.001) for PCOS patients and healthy women.
Conclusions: Smoking reduces ovarian blood flow in PCOS patients and healthy subjects. Smoke components effect the
vascular structure and form endothelial injuries that may reduce ovarian tissue perfusion. In this study, the positive correlation
between smoking and free androgen index shows that the main effect of smoking on ovarian blood flow may be
through androgen metabolism.
Abstract
Objectives: The objective of the current research is to compare hormonal, metabolic and ovarian stromal blood flow
outcomes in smoking versus non-smoking polycystic ovary syndrome (PCOS) patients.
Material and methods: 79 PCOS women (Group 1) and 79 healthy subjects (Group 2) were recruited. Both groups were
subdivided according to their smoking habits. Ovarian stromal blood flow was assessed with pulsatility and resistance
index for both ovaries and compared among smoking women.
Results: The smokers in the PCOS group had statistically significant higher levels of pulsatility and resistance index in both
ovaries compared to nonsmoker PCOS patients (p < 0.001). Comparison of ovarian stromal blood flow indexes shows that
pulsatility and resistance index for both ovaries is statistically significantly high in smoking healthy patients compared to
the nonsmoking group (p < 0.001). There is a positive correlation between smoking and free androgen index (r = 0.866,
p < 0.001) for PCOS patients and healthy women.
Conclusions: Smoking reduces ovarian blood flow in PCOS patients and healthy subjects. Smoke components effect the
vascular structure and form endothelial injuries that may reduce ovarian tissue perfusion. In this study, the positive correlation
between smoking and free androgen index shows that the main effect of smoking on ovarian blood flow may be
through androgen metabolism.
Keywords
polycystic ovary syndrome; smoking; ovarian stromal doppler; pulsatility index; resistance index; cardiovascular risk
About this articleTitle
Smoking reduces ovarian stromal blood flow in polycystic ovary syndrome patients
Journal
Issue
Article type
Research paper
Pages
201-206
Published online
2020-04-29
Page views
1642
Article views/downloads
1592
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(4):201-206.
Keywords
polycystic ovary syndrome
smoking
ovarian stromal doppler
pulsatility index
resistance index
cardiovascular risk
Authors
Özlen Emekçi Özay
Ali Cenk Özay
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