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Quantitative and qualitative Ductus Venosus blood flow evaluation in the screening for Trisomy 18 and 13 — suitability study
, 1, 1, 1, 1, 2, 3
Affiliations- Department of Obstetrics and Gynecology in Ruda Slaska, Medical University of Silesia, Ruda Slaska, Poland
- Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Faculty of Health Sciences, Department of Obstetrics, Bydgoszcz, Poland
- Department of Obstetrics and Perinatology, Faculty of Health Sciences, Medical University of Warsaw, Poland
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Abstract
Objectives: The objective of the paper is the suitability assessment of screening for Trisomy 18 and 13 on the basis of
nuchal translucency (NT) measurement, Fetal Heart Rate (FHR), double test, quantitative [Ductus Venosus (DV) Pulsatility
Index for Veins (PIV)] and qualitative (the A-wave assessment) blood flow evaluation in the DV.
Material and methods: The study was performed in 7296 singleton pregnancies. In each fetus NT, FHR, DV-PIV were
examined. Double test from maternal blood was examined. These ultrasound and biochemical factors were in combined
screening investigated. Additional doppler ultrasound markers such as abnormal a-wave in Ductus Venosus and Pusatility
Index for Veins of Ductus Venosus were and their impact on Trisomies 18 and 13 screening were examined.
Results: Two groups of patients were compared — with chromosomal normal and chromosomal abnormalities — Trisomy
18 and 13. Detection Rate of Trisomies 18 and 13 at the risk cutoff 1/300 using combined screening was 90.2% and FPR was
6%. Detection Rates of examined chromosomal abnormalities using contingent screening were: 92.1% using DV abnormal
a-wave and 94.84% using DV-PIV. FPR’s for booths parameters 5.8% and 5.4% respectively.
Conclusions: Quantitative analysis of the flow — assessment of DV-PIV in the first trimester significantly influences the
improvement of screening values focusing on Trisomy 18 and 13 detection.
Abstract
Objectives: The objective of the paper is the suitability assessment of screening for Trisomy 18 and 13 on the basis of
nuchal translucency (NT) measurement, Fetal Heart Rate (FHR), double test, quantitative [Ductus Venosus (DV) Pulsatility
Index for Veins (PIV)] and qualitative (the A-wave assessment) blood flow evaluation in the DV.
Material and methods: The study was performed in 7296 singleton pregnancies. In each fetus NT, FHR, DV-PIV were
examined. Double test from maternal blood was examined. These ultrasound and biochemical factors were in combined
screening investigated. Additional doppler ultrasound markers such as abnormal a-wave in Ductus Venosus and Pusatility
Index for Veins of Ductus Venosus were and their impact on Trisomies 18 and 13 screening were examined.
Results: Two groups of patients were compared — with chromosomal normal and chromosomal abnormalities — Trisomy
18 and 13. Detection Rate of Trisomies 18 and 13 at the risk cutoff 1/300 using combined screening was 90.2% and FPR was
6%. Detection Rates of examined chromosomal abnormalities using contingent screening were: 92.1% using DV abnormal
a-wave and 94.84% using DV-PIV. FPR’s for booths parameters 5.8% and 5.4% respectively.
Conclusions: Quantitative analysis of the flow — assessment of DV-PIV in the first trimester significantly influences the
improvement of screening values focusing on Trisomy 18 and 13 detection.
Keywords
Combined test trisomy 18 trisomy 13; first trimester nuchal translucency thickness; ductus venosus pulsatility index for veins; serum free β-hcg; pregnancy-associated plasma protein A
About this articleTitle
Quantitative and qualitative Ductus Venosus blood flow evaluation in the screening for Trisomy 18 and 13 — suitability study
Journal
Issue
Article type
Research paper
Pages
144-148
Published online
2020-03-31
Page views
1357
Article views/downloads
1236
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(3):144-148.
Keywords
Combined test trisomy 18 trisomy 13
first trimester nuchal translucency thickness
ductus venosus pulsatility index for veins
serum free β-hcg
pregnancy-associated plasma protein A
Authors
Bartosz Czuba
Malgorzata Nycz-Reska
Wojciech Cnota
Agnieszka Jagielska
Agata Wloch
Dariusz Borowski
Piotr Wegrzyn
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