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Vol 91, No 2 (2020)
Research paper
Published online: 2020-02-28
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The effect of lymph node metastasis on overall survival and disease-free survival in vulvar cancer patients

Volkan Karataşlı1, Selçuk Erkılınç1, İlker Çakır1, Behzat Can1, Tuğba Karadeniz2, Mehmet Gökçü1, Muzaffer Sancı1
DOI: 10.5603/GP.2020.0018
·
Pubmed: 32141050
·
Ginekol Pol 2020;91(2):62-67.
Affiliations
  1. Department of Gynecologic Oncology,University of Health Sciences Tepecik Education and Research Hospital, İzmir, Turkey
  2. Department of Pathology,University of Health Sciences Tepecik Education and Research Hospital, İzmir, Turkey

open access

Vol 91, No 2 (2020)
ORIGINAL PAPERS Gynecology
Published online: 2020-02-28

Abstract

Objectives: To examine the effect of lymphadenectomy on survival in patients with squamous cell vulvar carcinoma.
Material and methods: Patients with squamous cell vulvar cancer who underwent surgery were retrospectively analyzed.
All procedures were performed according to current recommendations/standard of treatment. The clinical and pathological
features were examined. Sixty-eight patients were studied. The mean age was 64.7 ± 10.9 years. Twenty-three (33.8%)
patients had nodal metastasis. Most patients (60.3%) were in stage IB. Adjuvant radiotherapy and chemo-radiotherapy were
administered to 33.8% and 25% of the patients, respectively. The median follow-up time was 28.5 (4–183) months. Recurrence
occurred in 18 (26.5%) cases.
Results: There was no significant difference between node-positive and node-negative patients in terms of age, number of
dissected lymph nodes and recurrence. Tumor diameter was significantly higher in the metastatic group. Age and surgical
margin positivity were independent prognostic factors for overall survival (OS). Surgical margin positivity and lymph node
metastasis had no effect on disease-free survival (DFS).
Conclusions: Our results showed that age and surgical margin positivity were independent prognostic factors for OS.
Although surgical margin positivity increased the risk of recurrence in univariate analysis, it was not a significant factor
affecting DFS. OS was significantly lower in patients with lymph node metastasis.

Abstract

Objectives: To examine the effect of lymphadenectomy on survival in patients with squamous cell vulvar carcinoma.
Material and methods: Patients with squamous cell vulvar cancer who underwent surgery were retrospectively analyzed.
All procedures were performed according to current recommendations/standard of treatment. The clinical and pathological
features were examined. Sixty-eight patients were studied. The mean age was 64.7 ± 10.9 years. Twenty-three (33.8%)
patients had nodal metastasis. Most patients (60.3%) were in stage IB. Adjuvant radiotherapy and chemo-radiotherapy were
administered to 33.8% and 25% of the patients, respectively. The median follow-up time was 28.5 (4–183) months. Recurrence
occurred in 18 (26.5%) cases.
Results: There was no significant difference between node-positive and node-negative patients in terms of age, number of
dissected lymph nodes and recurrence. Tumor diameter was significantly higher in the metastatic group. Age and surgical
margin positivity were independent prognostic factors for overall survival (OS). Surgical margin positivity and lymph node
metastasis had no effect on disease-free survival (DFS).
Conclusions: Our results showed that age and surgical margin positivity were independent prognostic factors for OS.
Although surgical margin positivity increased the risk of recurrence in univariate analysis, it was not a significant factor
affecting DFS. OS was significantly lower in patients with lymph node metastasis.

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Keywords

lymph node metastasis; prognostic factors; recurrence; squamous cell carcinoma; survival; vulvar cancer

About this article
Title

The effect of lymph node metastasis on overall survival and disease-free survival in vulvar cancer patients

Journal

Ginekologia Polska

Issue

Vol 91, No 2 (2020)

Article type

Research paper

Pages

62-67

Published online

2020-02-28

Page views

2123

Article views/downloads

896

DOI

10.5603/GP.2020.0018

Pubmed

32141050

Bibliographic record

Ginekol Pol 2020;91(2):62-67.

Keywords

lymph node metastasis
prognostic factors
recurrence
squamous cell carcinoma
survival
vulvar cancer

Authors

Volkan Karataşlı
Selçuk Erkılınç
İlker Çakır
Behzat Can
Tuğba Karadeniz
Mehmet Gökçü
Muzaffer Sancı

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