open access

Vol 91, No 1 (2020)
REVIEW PAPERS Obstetrics
Published online: 2020-01-31
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Endometrial microbiota — do they mean more than we have expected?

Natalia Mlodzik, Krzysztof Lukaszuk, Wlodzimierz Sieg, Grzegorz Jakiel, Roman Smolarczyk
DOI: 10.5603/GP.2020.0010
·
Pubmed: 32039468
·
Ginekol Pol 2020;91(1):45-48.

open access

Vol 91, No 1 (2020)
REVIEW PAPERS Obstetrics
Published online: 2020-01-31

Abstract

Low biomass microbiome has an increasing importance in today’s fertility studies. There are more and more indications
for incorporating upper gynecological tract microbiome content in patients diagnostic and in vitro fertilization process, as
doing so may help to evaluate chances for a positive outcome. An abnormal endometrial microbiota has been associated
with implantation failure, pregnancy loss, and other gynecological and obstetrical conditions. Furthermore it has been
shown, that using molecular methods in addition to routine diagnostics may help diagnose chronic endometritis or even
indicate cancerogenic changes. Understanding the significance of microbiome in endometrium may completely change
therapeutic approach in treatment of this part of reproductive tract. Next generation sequencing (NGS) has allowed to
isolate culturable and unculturable bacteria from female reproductive tract and is a cheaper and quicker alternative for
other widely known and used methods.

Abstract

Low biomass microbiome has an increasing importance in today’s fertility studies. There are more and more indications
for incorporating upper gynecological tract microbiome content in patients diagnostic and in vitro fertilization process, as
doing so may help to evaluate chances for a positive outcome. An abnormal endometrial microbiota has been associated
with implantation failure, pregnancy loss, and other gynecological and obstetrical conditions. Furthermore it has been
shown, that using molecular methods in addition to routine diagnostics may help diagnose chronic endometritis or even
indicate cancerogenic changes. Understanding the significance of microbiome in endometrium may completely change
therapeutic approach in treatment of this part of reproductive tract. Next generation sequencing (NGS) has allowed to
isolate culturable and unculturable bacteria from female reproductive tract and is a cheaper and quicker alternative for
other widely known and used methods.

Get Citation

Keywords

endometrium; microbiota; reproductive health; next generation sequencing

About this article
Title

Endometrial microbiota — do they mean more than we have expected?

Journal

Ginekologia Polska

Issue

Vol 91, No 1 (2020)

Pages

45-48

Published online

2020-01-31

DOI

10.5603/GP.2020.0010

Pubmed

32039468

Bibliographic record

Ginekol Pol 2020;91(1):45-48.

Keywords

endometrium
microbiota
reproductive health
next generation sequencing

Authors

Natalia Mlodzik
Krzysztof Lukaszuk
Wlodzimierz Sieg
Grzegorz Jakiel
Roman Smolarczyk

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