open access

Vol 90, No 12 (2019)
REVIEW PAPERS Gynecology
Published online: 2019-12-31
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Coexistence of tooth agenesis and ovarian cancer — a systematic literature review

Weronika Gawron-Jakubek, Joanna Spaczynska, Kazimierz Pitynski, Bartlomiej W. Loster
DOI: 10.5603/GP.2019.0121
·
Pubmed: 31909464
·
Ginekol Pol 2019;90(12):707-710.

open access

Vol 90, No 12 (2019)
REVIEW PAPERS Gynecology
Published online: 2019-12-31

Abstract

Objectives: Dental agenesis — a congenital lack of teeth — is one of the most frequently diagnosed developmental
defects of dentition. Genetics is a crucial factor in the etiology of this disorder. Missing teeth can be caused by mutation
in genes including MSX1, PAX9, AXIN2, and EDARADD. As is also true for ovarian cancer, over 20% of cases are associated
with hereditary factors. Mutations in the BRCA1 and BRCA2 genes are said to be the most frequent of these. The aim of
this study was to provide a systematic review of the literature on the coexistence of ovarian cancer and tooth agenesis.
Material and methods: Publications were searched for in the online databases PubMed, SCOPUS, and Wiley Online Library.
Current and archival issues of the Journal of Stomatology and Dental and Medical Problems were also searched. The key
words used to find relevant publications were: ovarian cancer, hypodontia, and tooth agenesis, in various combinations.
Results: Three publications were qualified to this review. Two of these compared the incidence of hypodontia in women
with ovarian cancer and in healthy women, and the other was aimed at locating the gene responsible for the coexistence
of ovarian cancer and tooth agenesis. As shown by these studies, women with ovarian cancer are (depending on the study)
3.3 or 8.1 times more likely to have hypodontia than healthy women. However, no specific gene was found that might be
responsible for the coexistence of ovarian cancer and tooth agenesis.

Abstract

Objectives: Dental agenesis — a congenital lack of teeth — is one of the most frequently diagnosed developmental
defects of dentition. Genetics is a crucial factor in the etiology of this disorder. Missing teeth can be caused by mutation
in genes including MSX1, PAX9, AXIN2, and EDARADD. As is also true for ovarian cancer, over 20% of cases are associated
with hereditary factors. Mutations in the BRCA1 and BRCA2 genes are said to be the most frequent of these. The aim of
this study was to provide a systematic review of the literature on the coexistence of ovarian cancer and tooth agenesis.
Material and methods: Publications were searched for in the online databases PubMed, SCOPUS, and Wiley Online Library.
Current and archival issues of the Journal of Stomatology and Dental and Medical Problems were also searched. The key
words used to find relevant publications were: ovarian cancer, hypodontia, and tooth agenesis, in various combinations.
Results: Three publications were qualified to this review. Two of these compared the incidence of hypodontia in women
with ovarian cancer and in healthy women, and the other was aimed at locating the gene responsible for the coexistence
of ovarian cancer and tooth agenesis. As shown by these studies, women with ovarian cancer are (depending on the study)
3.3 or 8.1 times more likely to have hypodontia than healthy women. However, no specific gene was found that might be
responsible for the coexistence of ovarian cancer and tooth agenesis.

Get Citation

Keywords

ovarian cancer; tooth agenesis; hypodontia

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About this article
Title

Coexistence of tooth agenesis and ovarian cancer — a systematic literature review

Journal

Ginekologia Polska

Issue

Vol 90, No 12 (2019)

Pages

707-710

Published online

2019-12-31

DOI

10.5603/GP.2019.0121

Pubmed

31909464

Bibliographic record

Ginekol Pol 2019;90(12):707-710.

Keywords

ovarian cancer
tooth agenesis
hypodontia

Authors

Weronika Gawron-Jakubek
Joanna Spaczynska
Kazimierz Pitynski
Bartlomiej W. Loster

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