open access

Vol 90, No 11 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-11-28
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Perinatal outcome in preterm premature rupture of membranes before 37 weeks of gestation

Malgorzata Swiatkowska-Freund, Anetta Traczyk-Łos, Anna Partyka, Kamil Obara, Altankhorol Damdinsuren, Krzysztof Preis
DOI: 10.5603/GP.2019.0109
·
Pubmed: 31802465
·
Ginekol Pol 2019;90(11):645-650.

open access

Vol 90, No 11 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-11-28

Abstract

Objectives: The aim of this study was to assess the maternal and neonatal outcome in patients with preterm premature rupture of membranes between 22 to 37 weeks of gestation in comparison to preterm birth patients. 

Material and methods: Group of PPROM patients consisted of 127 women, the control group counted 141 women who delivered prematurely. The control group was formed by matching patient with the same gestational age at delivery and neonatal birth weight to every woman from study group. In both groups speculum and ultrasound examinations were performed, microbiological swabs were taken. In unclear cases of PPROM tests detecting amniotic proteins, such as PAMG-1 or IGFBP-1, were performed. According to gestational age at delivery, neonates were divided into subgroups: extremely premature infants (< 27 weeks 6 days), moderate premature infants (from 28 weeks 0 days to 33 weeks 6 days), late premature infants (from 34 weeks 0 days to 37 weeks 0 days). 

Results: In the study group, median gestational age of delivery was 34 weeks 1 day and the same in control group — 34 weeks and 5 days (p > 0.05). Parameters of inflammatory status were more often reported in the PPROM group than in the preterm birth group, even if they weren’t statistically significant (positive culture of cervical swab, increased leukocytosis, CRP above 5). The rate of neonate survival was similar in both groups (93.7% and 94.1%). Congenital infection was more often diagnosed in group of neonates from PPROM pregnancies than in neonates from control group; (36% and 21.2% respectively; p = 0.009). 

Conclusions: Our research appears to be consistent with theory of inflammatory etiology of PPROM. Optimal management of infection in PPROM patients seems to be the most important in efforts to prolong pregnancy.

Abstract

Objectives: The aim of this study was to assess the maternal and neonatal outcome in patients with preterm premature rupture of membranes between 22 to 37 weeks of gestation in comparison to preterm birth patients. 

Material and methods: Group of PPROM patients consisted of 127 women, the control group counted 141 women who delivered prematurely. The control group was formed by matching patient with the same gestational age at delivery and neonatal birth weight to every woman from study group. In both groups speculum and ultrasound examinations were performed, microbiological swabs were taken. In unclear cases of PPROM tests detecting amniotic proteins, such as PAMG-1 or IGFBP-1, were performed. According to gestational age at delivery, neonates were divided into subgroups: extremely premature infants (< 27 weeks 6 days), moderate premature infants (from 28 weeks 0 days to 33 weeks 6 days), late premature infants (from 34 weeks 0 days to 37 weeks 0 days). 

Results: In the study group, median gestational age of delivery was 34 weeks 1 day and the same in control group — 34 weeks and 5 days (p > 0.05). Parameters of inflammatory status were more often reported in the PPROM group than in the preterm birth group, even if they weren’t statistically significant (positive culture of cervical swab, increased leukocytosis, CRP above 5). The rate of neonate survival was similar in both groups (93.7% and 94.1%). Congenital infection was more often diagnosed in group of neonates from PPROM pregnancies than in neonates from control group; (36% and 21.2% respectively; p = 0.009). 

Conclusions: Our research appears to be consistent with theory of inflammatory etiology of PPROM. Optimal management of infection in PPROM patients seems to be the most important in efforts to prolong pregnancy.

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Keywords

1 preterm delivery; 2 preterm premature rupture of membranes; 3 neonatology autcome

About this article
Title

Perinatal outcome in preterm premature rupture of membranes before 37 weeks of gestation

Journal

Ginekologia Polska

Issue

Vol 90, No 11 (2019)

Pages

645-650

Published online

2019-11-28

DOI

10.5603/GP.2019.0109

Pubmed

31802465

Bibliographic record

Ginekol Pol 2019;90(11):645-650.

Keywords

1 preterm delivery
2 preterm premature rupture of membranes
3 neonatology autcome

Authors

Malgorzata Swiatkowska-Freund
Anetta Traczyk-Łos
Anna Partyka
Kamil Obara
Altankhorol Damdinsuren
Krzysztof Preis

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