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Early potential metabolic biomarkers of primary postpartum haemorrhage based on serum metabolomics
Affiliations- Department of Gynacology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, China
open access
Abstract
Objectives: Postpartum hemorrhage (PPH) is the leading cause of maternal death, accounting for 1/4 of maternal deaths worldwide. Determining sensitive biomarkers in the peripheral blood to identify postpartum haemorrhage (PPH) is essential for the early diagnosis and management of PPH. The purpose of this study is to identify predictive serum metabolic biomarkers of PPH. Thirty healthy pregnant women and 30 cases of postpartum hemorrhage were studied for our research. Material and methods: The serum metabolites of all pregnant were detected by liquid chromatography-quadruple time-of-flight mass spectrometry (LC-QTOFMS) and the corresponding biomarkers were identified. Results: 34 significantly altered metabolites in PPH-pre-group were identified. They were mainly involved in fatty acid, and glycerophospholipid metabolism. Conclusions: The LysoPCs, PCs, PGs, PIs were effective biomarkers for identifying PPH. The disturbed signaling pathways, mTOR signaling, acute phase response signaling, AMPK signaling and eNOS signaling pathways might be related to the etiopathogenesis of PPH. Our study provided a valuable attempt to screen early diagnostic markers of PPH and to further understand its pathogenesis.
Abstract
Objectives: Postpartum hemorrhage (PPH) is the leading cause of maternal death, accounting for 1/4 of maternal deaths worldwide. Determining sensitive biomarkers in the peripheral blood to identify postpartum haemorrhage (PPH) is essential for the early diagnosis and management of PPH. The purpose of this study is to identify predictive serum metabolic biomarkers of PPH. Thirty healthy pregnant women and 30 cases of postpartum hemorrhage were studied for our research. Material and methods: The serum metabolites of all pregnant were detected by liquid chromatography-quadruple time-of-flight mass spectrometry (LC-QTOFMS) and the corresponding biomarkers were identified. Results: 34 significantly altered metabolites in PPH-pre-group were identified. They were mainly involved in fatty acid, and glycerophospholipid metabolism. Conclusions: The LysoPCs, PCs, PGs, PIs were effective biomarkers for identifying PPH. The disturbed signaling pathways, mTOR signaling, acute phase response signaling, AMPK signaling and eNOS signaling pathways might be related to the etiopathogenesis of PPH. Our study provided a valuable attempt to screen early diagnostic markers of PPH and to further understand its pathogenesis.
Keywords
biomarker; metabolomics; primary postpartum haemorrhage
About this articleTitle
Early potential metabolic biomarkers of primary postpartum haemorrhage based on serum metabolomics
Journal
Issue
Article type
Research paper
Pages
607-615
Published online
2019-10-31
Page views
1480
Article views/downloads
1192
DOI
Pubmed
Bibliographic record
Ginekol Pol 2019;90(10):607-615.
Keywords
biomarker
metabolomics
primary postpartum haemorrhage
Authors
Tingting Chen
Ruoxi Zhang
Yidong Zhang
Wenjun Yuan
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