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Vol 90, No 10 (2019)
Research paper
Published online: 2019-10-31
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GLUT 1 expression is a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma

Mohamad Nidal Khabaz1, Imtiaz Ahmad Qureshi1, Jaudah Ahmad Al-Maghrabi12
·
Pubmed: 31686415
·
Ginekol Pol 2019;90(10):582-588.
Affiliations
  1. Department of Pathology, Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  2. King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia

open access

Vol 90, No 10 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-10-31

Abstract

Objectives: This study will investigate the phenotype of Glucose transporter 1 (GLUT1) in endometrial cancer and the association of its expression with tumor’s clinicopathological factors.

Material and methods: Standard immunohistochemistry (IHC) staining protocol was utilized to identify the location and expression pattern of GLUT1 in a panel of 71 endometrial carcinomas compared to 30 normal tissues using tissue microarrays.

Results: High scores of GLUT1 staining are more frequent in cancer cases, it was recognized in 64 (90%) endometrial cancers and 12 (40%) control cases. Tissue histotype (cancer versus non-cancerous) was associated with IHC staining of GLUT1 (p = 0.000). Significant association between strong GLUT1 staining of malignant epithelial cells and stage of tumor (p = 0.000) was observed, advanced disease stages were more prevalent with high GLUT1 staining in malignant epithelial cells. There is also a significant association between high scores of GLUT1 staining and location of expression in transformed epithelium, cytoplasmic and membranous (p = 0.000), 100% of cases with cytoplasmic and membranous expression showed high GLUT1 staining scores. Considerable varied survival models were observed with positive GLUT 1 neoplasm regarding diagnosis, grade, stage, differentiation, and recurrence (p-values 0.000, 0.000, 0.000, 0.002, and 0.000 respectively). Survival estimates are considerably healthier in positive GLUT1 staining cases of endometrial carcinoma, which have low grade, low stage and no recurrence.

Conclusions: GLUT1 expression has been found upregulated in endometrial carcinoma. IHC staining of GLUT1 can be a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma with specific clinical factors.

Abstract

Objectives: This study will investigate the phenotype of Glucose transporter 1 (GLUT1) in endometrial cancer and the association of its expression with tumor’s clinicopathological factors.

Material and methods: Standard immunohistochemistry (IHC) staining protocol was utilized to identify the location and expression pattern of GLUT1 in a panel of 71 endometrial carcinomas compared to 30 normal tissues using tissue microarrays.

Results: High scores of GLUT1 staining are more frequent in cancer cases, it was recognized in 64 (90%) endometrial cancers and 12 (40%) control cases. Tissue histotype (cancer versus non-cancerous) was associated with IHC staining of GLUT1 (p = 0.000). Significant association between strong GLUT1 staining of malignant epithelial cells and stage of tumor (p = 0.000) was observed, advanced disease stages were more prevalent with high GLUT1 staining in malignant epithelial cells. There is also a significant association between high scores of GLUT1 staining and location of expression in transformed epithelium, cytoplasmic and membranous (p = 0.000), 100% of cases with cytoplasmic and membranous expression showed high GLUT1 staining scores. Considerable varied survival models were observed with positive GLUT 1 neoplasm regarding diagnosis, grade, stage, differentiation, and recurrence (p-values 0.000, 0.000, 0.000, 0.002, and 0.000 respectively). Survival estimates are considerably healthier in positive GLUT1 staining cases of endometrial carcinoma, which have low grade, low stage and no recurrence.

Conclusions: GLUT1 expression has been found upregulated in endometrial carcinoma. IHC staining of GLUT1 can be a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma with specific clinical factors.

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Keywords

GLUT1; immunohistochemistry; endometrial carcinoma

About this article
Title

GLUT 1 expression is a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma

Journal

Ginekologia Polska

Issue

Vol 90, No 10 (2019)

Article type

Research paper

Pages

582-588

Published online

2019-10-31

Page views

1278

Article views/downloads

1244

DOI

10.5603/GP.2019.0102

Pubmed

31686415

Bibliographic record

Ginekol Pol 2019;90(10):582-588.

Keywords

GLUT1
immunohistochemistry
endometrial carcinoma

Authors

Mohamad Nidal Khabaz
Imtiaz Ahmad Qureshi
Jaudah Ahmad Al-Maghrabi

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