open access

Vol 90, No 10 (2019)
Research paper
Published online: 2019-10-31
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The role of nesfatin and selected molecular factors in various types of endometrial cancer

Anna Markowska1, Monika Szarszewska2, Pawel Knapp3, Anna Grybos4, Marian Grybos5, Andrzej Marszalek6, Violetta Filas6, Katarzyna Wojcik-Krowiranda7, Malgorzata Swornik8, Janina Markowska2
·
Pubmed: 31686413
·
Ginekol Pol 2019;90(10):571-576.
Affiliations
  1. Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland
  2. Department of Oncology, Gynaecological Oncology, Poznan University of Medical Sciences, Poznan, Poland
  3. Department of Gynecology and Gynecologic Oncology, Medical University of Bialystok, Bialystok, Poland
  4. Department of Gyneacology and Obstetrics, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland
  5. Medical School in Opole, Opole, Poland
  6. Department of Tumour Pathology and Prophylaxis, Poznan University of Medical Sciences, Greater Poland Cancer Centre, Poznan, Poland
  7. Medical University of Lodz, Gynecological-Oncology, Lodz, Poland
  8. Gynecological Endocrinology Department, Jagiellonian University Medical College, Krakow, Poland

open access

Vol 90, No 10 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-10-31

Abstract

Objectives: Endometrial cancers (ECs) are the most common gynaecological cancers in well developed countries. Diabetes and metabolic syndrome are among the biggest risk factors. Nesfatin-1, the adipokine derivative of NUCB2 (nucleobindin derivative 2) is linked to the clinical course of EC. Molecular factors, including mutations in MLH1 and MHS2 genes, c-MET and ARID1A are also related to prognosis in endometrial cancer. Material and methods: Using sections of paraffin-embedded preparations and immunohistochemistry, the expression of NESF1, MLH1, MSH2,c-MET and ARID1A were examined. Results: In this study on protein expression, EC tissues manifested (although insignificantly) an elevated expression of NESF-1 in type II EC. In type I EC, NESF-1 expression was significantly higher in G1 in comparison to G2 and G3 together. A significantly lower expression of MLH1 was demonstrated in type I EC. Conclusions: The most pronounced expression involved c-MET in all EC I and EC II tissues (in over 80% of cases). A tendency was detected for a high expression of NESF-1 in patients with type II EC, who also exhibited a high expression of MSH2.

Abstract

Objectives: Endometrial cancers (ECs) are the most common gynaecological cancers in well developed countries. Diabetes and metabolic syndrome are among the biggest risk factors. Nesfatin-1, the adipokine derivative of NUCB2 (nucleobindin derivative 2) is linked to the clinical course of EC. Molecular factors, including mutations in MLH1 and MHS2 genes, c-MET and ARID1A are also related to prognosis in endometrial cancer. Material and methods: Using sections of paraffin-embedded preparations and immunohistochemistry, the expression of NESF1, MLH1, MSH2,c-MET and ARID1A were examined. Results: In this study on protein expression, EC tissues manifested (although insignificantly) an elevated expression of NESF-1 in type II EC. In type I EC, NESF-1 expression was significantly higher in G1 in comparison to G2 and G3 together. A significantly lower expression of MLH1 was demonstrated in type I EC. Conclusions: The most pronounced expression involved c-MET in all EC I and EC II tissues (in over 80% of cases). A tendency was detected for a high expression of NESF-1 in patients with type II EC, who also exhibited a high expression of MSH2.

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Keywords

endometrial cancer; NESF-1; MLH1; MSH2; c-MET; ARID1A

About this article
Title

The role of nesfatin and selected molecular factors in various types of endometrial cancer

Journal

Ginekologia Polska

Issue

Vol 90, No 10 (2019)

Article type

Research paper

Pages

571-576

Published online

2019-10-31

Page views

1961

Article views/downloads

1438

DOI

10.5603/GP.2019.0099

Pubmed

31686413

Bibliographic record

Ginekol Pol 2019;90(10):571-576.

Keywords

endometrial cancer
NESF-1
MLH1
MSH2
c-MET
ARID1A

Authors

Anna Markowska
Monika Szarszewska
Pawel Knapp
Anna Grybos
Marian Grybos
Andrzej Marszalek
Violetta Filas
Katarzyna Wojcik-Krowiranda
Malgorzata Swornik
Janina Markowska

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