open access

Vol 90, No 10 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-10-31
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The value of PET/CT in determining lymph node metastasis of endometrial cancer

Emine Budak, Ahmet Yanarateş
DOI: 10.5603/GP.2019.0098
·
Pubmed: 31686412
·
Ginekol Pol 2019;90(10):565-570.

open access

Vol 90, No 10 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-10-31

Abstract

Objectives: In our study, the role of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in determining lymph node metastasis of endometrial cancer was evaluated.

Material and methods: The present retrospectively registered study included 80 patients with endometrial cancer who underwent PET/CT in preoperative period. The patients underwent total hysterectomy with bilateral salpingo-oophorectomy and lymph node dissection. Lymph node status was evaluated in histopathologic examination and PET/CT imaging and, the results were compared.

Results: There were 80 patients (mean age 62 years) in the present study. Lymph node metastasis was detected in five patients, whereas 75 patients had no lymph node metastasis. A total of 1,471 lymph nodes were examined histopathologically, revealing benign findings in 1,433 (pelvic = 1018, paraaortic = 415) and malignant findings in 38 (pelvic = 28, paraaortic = 10) lymph nodes. The accuracy, sensitivity and specificity of PET/CT in determining lymph node metastasis was 95%, 80% and 96% in patient-based evaluation, and 97.4%, 78.9% and 98.6% in lymph node-based evaluation, respectively. The detection sensitivity of PET/CT was 0%, 81.4% and 100% in metastatic lymph nodes with a short diameter of ≤ 4 mm, 5–9 mm and ≥ 10 mm, respectively. PET/CT could detect 73.3% of metastatic lymph nodes that had < 10 mm short diameter.

Conclusions: PET/CT is useful method in detecting lymph node metastasis especially that are disregarded by CT or MR in endometrial cancer. Although PET/CT doesn’t fully replace the surgical staging, its utilization in preoperative period may guide surgical procedure.

Abstract

Objectives: In our study, the role of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in determining lymph node metastasis of endometrial cancer was evaluated.

Material and methods: The present retrospectively registered study included 80 patients with endometrial cancer who underwent PET/CT in preoperative period. The patients underwent total hysterectomy with bilateral salpingo-oophorectomy and lymph node dissection. Lymph node status was evaluated in histopathologic examination and PET/CT imaging and, the results were compared.

Results: There were 80 patients (mean age 62 years) in the present study. Lymph node metastasis was detected in five patients, whereas 75 patients had no lymph node metastasis. A total of 1,471 lymph nodes were examined histopathologically, revealing benign findings in 1,433 (pelvic = 1018, paraaortic = 415) and malignant findings in 38 (pelvic = 28, paraaortic = 10) lymph nodes. The accuracy, sensitivity and specificity of PET/CT in determining lymph node metastasis was 95%, 80% and 96% in patient-based evaluation, and 97.4%, 78.9% and 98.6% in lymph node-based evaluation, respectively. The detection sensitivity of PET/CT was 0%, 81.4% and 100% in metastatic lymph nodes with a short diameter of ≤ 4 mm, 5–9 mm and ≥ 10 mm, respectively. PET/CT could detect 73.3% of metastatic lymph nodes that had < 10 mm short diameter.

Conclusions: PET/CT is useful method in detecting lymph node metastasis especially that are disregarded by CT or MR in endometrial cancer. Although PET/CT doesn’t fully replace the surgical staging, its utilization in preoperative period may guide surgical procedure.

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Keywords

FDG PET/CT; endometrial cancer; lymph node metastasis

About this article
Title

The value of PET/CT in determining lymph node metastasis of endometrial cancer

Journal

Ginekologia Polska

Issue

Vol 90, No 10 (2019)

Pages

565-570

Published online

2019-10-31

DOI

10.5603/GP.2019.0098

Pubmed

31686412

Bibliographic record

Ginekol Pol 2019;90(10):565-570.

Keywords

FDG PET/CT
endometrial cancer
lymph node metastasis

Authors

Emine Budak
Ahmet Yanarateş

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