open access

Vol 90, No 10 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-10-31
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The relationship between IGF1 and the expression spectrum of miRNA in the placenta of preeclampsia patients

Xiaoju He, Lu Zhao, Lulu Yue, Wei Zhang, Wanzhen Wang, Yuanping Fu, Yueying Feng, Fen Fu
DOI: 10.5603/GP.2019.0096
·
Pubmed: 31686417
·
Ginekol Pol 2019;90(10):596-603.

open access

Vol 90, No 10 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-10-31

Abstract

Objectives: Pre-eclampsia (PE) affects many women worldwide and remains the leading cause of morbidity and mortality in neonatal and maternal settings. Abnormal expression of placental microRNAs (miRNAs) may be associated with PE.

Material and methods: This study was conducted to the relationship between IGF1 and the expression spectrum of miRNA in the placenta of preeclampsia patient. The expression of miRNA in placental tissue was compared between pre-eclampsia (n = 6) and normal pregnant women (n = 5) miRNA targets were studied by computer simulation and functional assays. The role of miRNA was verified in trophoblast cell lines by apoptosis assay and invasion assay.

Results: There was a significant increase in miRNAs in the placenta of women with pre-eclampsia compared with patients with normal pregnancy. Luciferase assay confirmed direct regulation of miRNA.

Conclusions: The expression of IGF1 and miRNA was significantly increased in the placenta of patients with pre-eclampsia.

Abstract

Objectives: Pre-eclampsia (PE) affects many women worldwide and remains the leading cause of morbidity and mortality in neonatal and maternal settings. Abnormal expression of placental microRNAs (miRNAs) may be associated with PE.

Material and methods: This study was conducted to the relationship between IGF1 and the expression spectrum of miRNA in the placenta of preeclampsia patient. The expression of miRNA in placental tissue was compared between pre-eclampsia (n = 6) and normal pregnant women (n = 5) miRNA targets were studied by computer simulation and functional assays. The role of miRNA was verified in trophoblast cell lines by apoptosis assay and invasion assay.

Results: There was a significant increase in miRNAs in the placenta of women with pre-eclampsia compared with patients with normal pregnancy. Luciferase assay confirmed direct regulation of miRNA.

Conclusions: The expression of IGF1 and miRNA was significantly increased in the placenta of patients with pre-eclampsia.

Get Citation

Keywords

preeclampsia; IGF1; miRNA; placenta; expression spectrum

About this article
Title

The relationship between IGF1 and the expression spectrum of miRNA in the placenta of preeclampsia patients

Journal

Ginekologia Polska

Issue

Vol 90, No 10 (2019)

Pages

596-603

Published online

2019-10-31

DOI

10.5603/GP.2019.0096

Pubmed

31686417

Bibliographic record

Ginekol Pol 2019;90(10):596-603.

Keywords

preeclampsia
IGF1
miRNA
placenta
expression spectrum

Authors

Xiaoju He
Lu Zhao
Lulu Yue
Wei Zhang
Wanzhen Wang
Yuanping Fu
Yueying Feng
Fen Fu

References (18)
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