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Vol 90, No 7 (2019)
Research paper
Published online: 2019-07-26
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Therapeutic hypothermia in asphyxiated newborns: selective head cooling vs. whole body cooling — comparison of short term outcomes

Ewa Matylda Gulczynska1, Janusz Gadzinowski2, Marcin Kesiak1, Barbara Sobolewska1, Joanna Caputa2, Anna Maczko3, Wojciech Walas3, Wioletta Cedrowska-Adamus1, Tomasz Talar3
DOI: 10.5603/GP.2019.0069
·
Pubmed: 31392710
·
Ginekol Pol 2019;90(7):403-410.
Affiliations
  1. Department of Neonatology, Polish Mother Memorial Hospital — Research Institute, Lodz, Poland
  2. Department of Neonatology, Poznan University of Medical Sciences, Poznan, Polska
  3. Pediatric Intensive Care Unit, University Hospital in Opole, Poland

open access

Vol 90, No 7 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-07-26

Abstract

Objectives: Therapeutic hypothermia TH became broadly used in the management of the asphyxiated newborns. Although two cooling methods are used, so far the superiority of none of them has been established. The purpose of the study is to compare two cooling methods: selective head cooling (SHC) and whole body cooling (WBC)

Material and methods: We conducted a prospective observational study in newborns with HIE. The patients received one of methods: SHC or WBC. The eligibility criteria were similar to previous studies. Stability of cardio-respiratory parameters and short term outcomes were analyzed.

Results: 78 neonates with hypoxic-ischemic encephalopathy due to perinatal asphyxia were involved in this study. The SHC group consisted of 51 newborns, the WBC group consisted of 27 patients. Both study groups had similar baseline characteristics and condition at birth. There were no significant differences in hospital course, neurological status and adverse effects associated with cooling procedure between groups. Analyzing the rate of thrombocytopenia and the number of transfusions of blood components no statistically significant differences were found between the groups.

Conclusions: Results of our study indicate that two compared methods of TH despite varied target core temperature ranges do not differ significantly according to clinical course and risk of adverse events. Further observations are conducted and we look forward to the results of the long neurodevelopmental care.

Abstract

Objectives: Therapeutic hypothermia TH became broadly used in the management of the asphyxiated newborns. Although two cooling methods are used, so far the superiority of none of them has been established. The purpose of the study is to compare two cooling methods: selective head cooling (SHC) and whole body cooling (WBC)

Material and methods: We conducted a prospective observational study in newborns with HIE. The patients received one of methods: SHC or WBC. The eligibility criteria were similar to previous studies. Stability of cardio-respiratory parameters and short term outcomes were analyzed.

Results: 78 neonates with hypoxic-ischemic encephalopathy due to perinatal asphyxia were involved in this study. The SHC group consisted of 51 newborns, the WBC group consisted of 27 patients. Both study groups had similar baseline characteristics and condition at birth. There were no significant differences in hospital course, neurological status and adverse effects associated with cooling procedure between groups. Analyzing the rate of thrombocytopenia and the number of transfusions of blood components no statistically significant differences were found between the groups.

Conclusions: Results of our study indicate that two compared methods of TH despite varied target core temperature ranges do not differ significantly according to clinical course and risk of adverse events. Further observations are conducted and we look forward to the results of the long neurodevelopmental care.

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Keywords

asphyxia; hypoxic–ischemic encephalopathy; newborn; selective head cooling; whole-body cooling

About this article
Title

Therapeutic hypothermia in asphyxiated newborns: selective head cooling vs. whole body cooling — comparison of short term outcomes

Journal

Ginekologia Polska

Issue

Vol 90, No 7 (2019)

Article type

Research paper

Pages

403-410

Published online

2019-07-26

Page views

2760

Article views/downloads

1963

DOI

10.5603/GP.2019.0069

Pubmed

31392710

Bibliographic record

Ginekol Pol 2019;90(7):403-410.

Keywords

asphyxia
hypoxic–ischemic encephalopathy
newborn
selective head cooling
whole-body cooling

Authors

Ewa Matylda Gulczynska
Janusz Gadzinowski
Marcin Kesiak
Barbara Sobolewska
Joanna Caputa
Anna Maczko
Wojciech Walas
Wioletta Cedrowska-Adamus
Tomasz Talar

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