open access

Vol 90, No 5 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-05-31
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Is polycystic ovarian syndrome and insulin resistance associated with abnormal uterine bleeding in adolescents?

Ewa Urbanska, Lidia Hirnle, Magdalena Olszanecka-Glinianowicz, Violetta Skrzypulec-Plinta, Agnieszka Skrzypulec-Frankel, Agnieszka Drosdzol-Cop
DOI: 10.5603/GP.2019.0049
·
Pubmed: 31165465
·
Ginekol Pol 2019;90(5):262-269.

open access

Vol 90, No 5 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-05-31

Abstract

Objectives: The aim of the study was to determine if adolescents with juvenile bleeding had polycystic ovarian syndrome (PCOS) and insulin resistance. 

Material and methods: The study was conducted in a group of 43 females aged 12–18 years, diagnosed with juvenile menorrhagia, and 37 healthy female adolescents aged 12–18 years. The study was conducted during the early follicular phase of the menstrual cycle. Menstrual cycle disturbances, acne and hirsutism were recorded. Ultrasound scan determining the condition of the ovaries was conducted. Laboratory tests of the glucose level, cholesterol, LDL and HDL cholesterol and triglycerides fraction, DHEAS, FSH, LH, insulin, SHGB, total testosterone, androstenedione, and free testosterone have been established. 

Results: The occurrence of regular menstrual cycles (30.23%, p = 0.006) was significantly lower in the juvenile bleeding group. Also, secondary amenorrhea was significantly more likely to be recognized in this group of females (p = 0.03). The concentration of FSH was considerably lower (p = 0.0002) in the group of adolescents with AUB. 

Conclusions: Adolescents with abnormal uterine bleeding (AUB) are often diagnosed with secondary amenorrhea, and PCOS. The group with a diagnosis of juvenile bleeding was also diagnosed with higher rates of insulin resistance. 

Abstract

Objectives: The aim of the study was to determine if adolescents with juvenile bleeding had polycystic ovarian syndrome (PCOS) and insulin resistance. 

Material and methods: The study was conducted in a group of 43 females aged 12–18 years, diagnosed with juvenile menorrhagia, and 37 healthy female adolescents aged 12–18 years. The study was conducted during the early follicular phase of the menstrual cycle. Menstrual cycle disturbances, acne and hirsutism were recorded. Ultrasound scan determining the condition of the ovaries was conducted. Laboratory tests of the glucose level, cholesterol, LDL and HDL cholesterol and triglycerides fraction, DHEAS, FSH, LH, insulin, SHGB, total testosterone, androstenedione, and free testosterone have been established. 

Results: The occurrence of regular menstrual cycles (30.23%, p = 0.006) was significantly lower in the juvenile bleeding group. Also, secondary amenorrhea was significantly more likely to be recognized in this group of females (p = 0.03). The concentration of FSH was considerably lower (p = 0.0002) in the group of adolescents with AUB. 

Conclusions: Adolescents with abnormal uterine bleeding (AUB) are often diagnosed with secondary amenorrhea, and PCOS. The group with a diagnosis of juvenile bleeding was also diagnosed with higher rates of insulin resistance. 

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Keywords

abnormal uterine bleeding; polycystic ovarian syndrome; hyperandrogenism; insulin resistance

About this article
Title

Is polycystic ovarian syndrome and insulin resistance associated with abnormal uterine bleeding in adolescents?

Journal

Ginekologia Polska

Issue

Vol 90, No 5 (2019)

Pages

262-269

Published online

2019-05-31

DOI

10.5603/GP.2019.0049

Pubmed

31165465

Bibliographic record

Ginekol Pol 2019;90(5):262-269.

Keywords

abnormal uterine bleeding
polycystic ovarian syndrome
hyperandrogenism
insulin resistance

Authors

Ewa Urbanska
Lidia Hirnle
Magdalena Olszanecka-Glinianowicz
Violetta Skrzypulec-Plinta
Agnieszka Skrzypulec-Frankel
Agnieszka Drosdzol-Cop

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