open access

Vol 90, No 4 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-04-29
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Short-term dexamethasone plus acetylsalicylic acid treatment during in vitro fertilization procedure

Dejan Mitic, Jelena M. Milenkovic, Maja Milojkovic, Miljan Jeremic, Aleksandra Petric, Marin Basic
DOI: 10.5603/GP.2019.0036
·
Pubmed: 31059112
·
Ginekol Pol 2019;90(4):201-205.

open access

Vol 90, No 4 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-04-29

Abstract

Objectives: Embryo implantation represents the major limiting step during in vitro fertilization (IVF) procedure. Immu- nological and coagulation abnormalities were shown to have a substantial part in multifactorial etiology of IVF failure. We aimed to investigate the effect of short-term low-dose dexamethasone plus acetylsalicylic acid (ASA) treatment, starting at the time of embryo transfer, on the implantation and clinical pregnancy rates in general IVF population. 

Material and methods: Out of 233 consecutive patients undergoing fresh IVF/intracytoplasmic sperm injection (ICSI) cycles 64 received an adjuvant treatment consisting of dexamethasone (0.5 mg/day) plus ASA (100 mg/day) (DA group), starting on the day of embryo transfer. Patients not receiving these medications comprised a control group. 

Results: Significantly more patients in DA group had positive ß-hCG values than controls (59.38% vs. 37.67%, p = 0.004) (OR = 2.42, 95% CI: 1.33–4.41). Implantation rate was 26.53% in DA group and 15.92% in controls (p = 0.0294). Clinical preg- nancy rate per started cycle was higher in DA group (43.59%) than controls (28.92%), but the difference was not significant (p = 0.0879; OR = 1.99, 95% CI: 0.89–4.41). 

Conclusions: Our study shows a potential benefit of dexamethasone plus ASA adjuvant treatment in females undergoing IVF/ICSI procedure. As these results show improvement of IVF outcome, a greater number of patients undergoing this type and regime of adjuvant treatment should be investigated. 

Abstract

Objectives: Embryo implantation represents the major limiting step during in vitro fertilization (IVF) procedure. Immu- nological and coagulation abnormalities were shown to have a substantial part in multifactorial etiology of IVF failure. We aimed to investigate the effect of short-term low-dose dexamethasone plus acetylsalicylic acid (ASA) treatment, starting at the time of embryo transfer, on the implantation and clinical pregnancy rates in general IVF population. 

Material and methods: Out of 233 consecutive patients undergoing fresh IVF/intracytoplasmic sperm injection (ICSI) cycles 64 received an adjuvant treatment consisting of dexamethasone (0.5 mg/day) plus ASA (100 mg/day) (DA group), starting on the day of embryo transfer. Patients not receiving these medications comprised a control group. 

Results: Significantly more patients in DA group had positive ß-hCG values than controls (59.38% vs. 37.67%, p = 0.004) (OR = 2.42, 95% CI: 1.33–4.41). Implantation rate was 26.53% in DA group and 15.92% in controls (p = 0.0294). Clinical preg- nancy rate per started cycle was higher in DA group (43.59%) than controls (28.92%), but the difference was not significant (p = 0.0879; OR = 1.99, 95% CI: 0.89–4.41). 

Conclusions: Our study shows a potential benefit of dexamethasone plus ASA adjuvant treatment in females undergoing IVF/ICSI procedure. As these results show improvement of IVF outcome, a greater number of patients undergoing this type and regime of adjuvant treatment should be investigated. 

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Keywords

embryo implantation; pregnancy rate; assisted reproductive techniques; spontaneous abortion; coagulation disorders; glucocorticoid effects

About this article
Title

Short-term dexamethasone plus acetylsalicylic acid treatment during in vitro fertilization procedure

Journal

Ginekologia Polska

Issue

Vol 90, No 4 (2019)

Pages

201-205

Published online

2019-04-29

DOI

10.5603/GP.2019.0036

Pubmed

31059112

Bibliographic record

Ginekol Pol 2019;90(4):201-205.

Keywords

embryo implantation
pregnancy rate
assisted reproductive techniques
spontaneous abortion
coagulation disorders
glucocorticoid effects

Authors

Dejan Mitic
Jelena M. Milenkovic
Maja Milojkovic
Miljan Jeremic
Aleksandra Petric
Marin Basic

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