open access

Vol 90, No 4 (2019)
Research paper
Published online: 2019-04-29
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Short-term dexamethasone plus acetylsalicylic acid treatment during in vitro fertilization procedure

Dejan Mitic1, Jelena M. Milenkovic2, Maja Milojkovic2, Miljan Jeremic3, Aleksandra Petric1, Marin Basic1
·
Pubmed: 31059112
·
Ginekol Pol 2019;90(4):201-205.
Affiliations
  1. Gynecology and Obstetrics Clinic, Clinical Center Nis, Faculty of Medicine, University of Nis, Serbia
  2. Department of Pathophysiology, Faculty of Medicine, University of Nis, Serbia
  3. Faculty of Medicine, University of Nis, Serbia

open access

Vol 90, No 4 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-04-29

Abstract

Objectives: Embryo implantation represents the major limiting step during in vitro fertilization (IVF) procedure. Immu- nological and coagulation abnormalities were shown to have a substantial part in multifactorial etiology of IVF failure. We aimed to investigate the effect of short-term low-dose dexamethasone plus acetylsalicylic acid (ASA) treatment, starting at the time of embryo transfer, on the implantation and clinical pregnancy rates in general IVF population. 

Material and methods: Out of 233 consecutive patients undergoing fresh IVF/intracytoplasmic sperm injection (ICSI) cycles 64 received an adjuvant treatment consisting of dexamethasone (0.5 mg/day) plus ASA (100 mg/day) (DA group), starting on the day of embryo transfer. Patients not receiving these medications comprised a control group. 

Results: Significantly more patients in DA group had positive ß-hCG values than controls (59.38% vs. 37.67%, p = 0.004) (OR = 2.42, 95% CI: 1.33–4.41). Implantation rate was 26.53% in DA group and 15.92% in controls (p = 0.0294). Clinical preg- nancy rate per started cycle was higher in DA group (43.59%) than controls (28.92%), but the difference was not significant (p = 0.0879; OR = 1.99, 95% CI: 0.89–4.41). 

Conclusions: Our study shows a potential benefit of dexamethasone plus ASA adjuvant treatment in females undergoing IVF/ICSI procedure. As these results show improvement of IVF outcome, a greater number of patients undergoing this type and regime of adjuvant treatment should be investigated. 

Abstract

Objectives: Embryo implantation represents the major limiting step during in vitro fertilization (IVF) procedure. Immu- nological and coagulation abnormalities were shown to have a substantial part in multifactorial etiology of IVF failure. We aimed to investigate the effect of short-term low-dose dexamethasone plus acetylsalicylic acid (ASA) treatment, starting at the time of embryo transfer, on the implantation and clinical pregnancy rates in general IVF population. 

Material and methods: Out of 233 consecutive patients undergoing fresh IVF/intracytoplasmic sperm injection (ICSI) cycles 64 received an adjuvant treatment consisting of dexamethasone (0.5 mg/day) plus ASA (100 mg/day) (DA group), starting on the day of embryo transfer. Patients not receiving these medications comprised a control group. 

Results: Significantly more patients in DA group had positive ß-hCG values than controls (59.38% vs. 37.67%, p = 0.004) (OR = 2.42, 95% CI: 1.33–4.41). Implantation rate was 26.53% in DA group and 15.92% in controls (p = 0.0294). Clinical preg- nancy rate per started cycle was higher in DA group (43.59%) than controls (28.92%), but the difference was not significant (p = 0.0879; OR = 1.99, 95% CI: 0.89–4.41). 

Conclusions: Our study shows a potential benefit of dexamethasone plus ASA adjuvant treatment in females undergoing IVF/ICSI procedure. As these results show improvement of IVF outcome, a greater number of patients undergoing this type and regime of adjuvant treatment should be investigated. 

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Keywords

embryo implantation; pregnancy rate; assisted reproductive techniques; spontaneous abortion; coagulation disorders; glucocorticoid effects

About this article
Title

Short-term dexamethasone plus acetylsalicylic acid treatment during in vitro fertilization procedure

Journal

Ginekologia Polska

Issue

Vol 90, No 4 (2019)

Article type

Research paper

Pages

201-205

Published online

2019-04-29

Page views

2249

Article views/downloads

3104

DOI

10.5603/GP.2019.0036

Pubmed

31059112

Bibliographic record

Ginekol Pol 2019;90(4):201-205.

Keywords

embryo implantation
pregnancy rate
assisted reproductive techniques
spontaneous abortion
coagulation disorders
glucocorticoid effects

Authors

Dejan Mitic
Jelena M. Milenkovic
Maja Milojkovic
Miljan Jeremic
Aleksandra Petric
Marin Basic

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