open access

Vol 90, No 2 (2019)
REVIEW PAPERS Obstetrics
Published online: 2019-02-28
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The role of lymphocytes in fetal development and recurrent pregnancy loss

Jan Modzelewski, Anna Kajdy, Michal Rabijewski
DOI: 10.5603/GP.2019.0019
·
Pubmed: 30860279
·
Ginekol Pol 2019;90(2):109-113.

open access

Vol 90, No 2 (2019)
REVIEW PAPERS Obstetrics
Published online: 2019-02-28

Abstract

Fetal survival and development is supported by the maternal immune system. Questions regarding those mechanisms have risen from development of transplantation medicine and observation of graft rejection. Initial theories of anatomic division, fetal immune immaturity and maternal immune system inertia were found incorrect. Rejection of fetal “semi-allograft” by maternal immune system could result in pregnancy loss. Two pregnancy losses of any etiology are considered recurrent and effort should be made to name the probable cause. Immune causes of pregnancy loss are probably multifactorial, thus difficult to research and implement findings in clinical practice. Although a full understating of pregnancy loss is not established, new therapies are being developed. This review summarizes the role of lymphocytes in pregnancy develop- ment, presents data from studies on recurrent pregnancy loss patients, evidence of new therapies and ESHRE guidelines regarding immunologic investigations. 

Abstract

Fetal survival and development is supported by the maternal immune system. Questions regarding those mechanisms have risen from development of transplantation medicine and observation of graft rejection. Initial theories of anatomic division, fetal immune immaturity and maternal immune system inertia were found incorrect. Rejection of fetal “semi-allograft” by maternal immune system could result in pregnancy loss. Two pregnancy losses of any etiology are considered recurrent and effort should be made to name the probable cause. Immune causes of pregnancy loss are probably multifactorial, thus difficult to research and implement findings in clinical practice. Although a full understating of pregnancy loss is not established, new therapies are being developed. This review summarizes the role of lymphocytes in pregnancy develop- ment, presents data from studies on recurrent pregnancy loss patients, evidence of new therapies and ESHRE guidelines regarding immunologic investigations. 

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Keywords

recurrent pregnancy loss; lymphocytes; Treg; Th17; uNK; abortion; habitual

About this article
Title

The role of lymphocytes in fetal development and recurrent pregnancy loss

Journal

Ginekologia Polska

Issue

Vol 90, No 2 (2019)

Pages

109-113

Published online

2019-02-28

DOI

10.5603/GP.2019.0019

Pubmed

30860279

Bibliographic record

Ginekol Pol 2019;90(2):109-113.

Keywords

recurrent pregnancy loss
lymphocytes
Treg
Th17
uNK
abortion
habitual

Authors

Jan Modzelewski
Anna Kajdy
Michal Rabijewski

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