open access

Vol 90, No 1 (2019)
Research paper
Published online: 2019-01-31
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Peroxiredoxin-5 is a negative survival predictor in ovarian cancer

Jacek Sienko1, Pawel Gaj2, Krzysztof Czajkowski1, Dominika Nowis345
·
Pubmed: 30756364
·
Ginekol Pol 2019;90(1):1-6.
Affiliations
  1. 2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland
  2. Laboratory of Human Cancer Genetics, Center of New Technologies, University of Warsaw, Poland
  3. Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Poland
  4. Laboratory of Experimental Medicine, Center of New Technologies, University of Warsaw, Poland
  5. Department of Genomic Medicine, Medical University of Warsaw, Poland

open access

Vol 90, No 1 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-01-31

Abstract

Objectives: Peroxiredoxins (PRDXs) constitute a family of antioxidant enzymes which are also involved in the process of carcinogenesis. They are composed of six identified isoforms (PRDX-1-6) and are supposed to play different roles in tumor progression, depending on type of cancer and member of the PRDX family. The aim of the study was to assess the prog- nostic value of PRDXs in ovarian cancer. Material and methods: a dataset of patients with ovarian cancer from The Cancer Genome Atlas was analyzed. Expression of PRDX-1 to 6 mRNA was evaluated in 260 samples. The prognostic value of PRDXs was assessed using the Cox regression model which included the following clinical and pathological data: age, clinical stage, tumor grade, and residual disease. Results: Within the PRDXs family, only higher expression of PRDX-5 was associated with worse overall survival both, in unselected patients and > 50-year-olds. PRDX-5 expression and residual disease were independent negative prognostic factors of patient survival. Conclusions: PRDX-5 is a negative predictor of survival in ovarian cancer.  

Abstract

Objectives: Peroxiredoxins (PRDXs) constitute a family of antioxidant enzymes which are also involved in the process of carcinogenesis. They are composed of six identified isoforms (PRDX-1-6) and are supposed to play different roles in tumor progression, depending on type of cancer and member of the PRDX family. The aim of the study was to assess the prog- nostic value of PRDXs in ovarian cancer. Material and methods: a dataset of patients with ovarian cancer from The Cancer Genome Atlas was analyzed. Expression of PRDX-1 to 6 mRNA was evaluated in 260 samples. The prognostic value of PRDXs was assessed using the Cox regression model which included the following clinical and pathological data: age, clinical stage, tumor grade, and residual disease. Results: Within the PRDXs family, only higher expression of PRDX-5 was associated with worse overall survival both, in unselected patients and > 50-year-olds. PRDX-5 expression and residual disease were independent negative prognostic factors of patient survival. Conclusions: PRDX-5 is a negative predictor of survival in ovarian cancer.  

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Keywords

peroxiredoxin-5; ovarian cancer; prognostic factor; overall survival

About this article
Title

Peroxiredoxin-5 is a negative survival predictor in ovarian cancer

Journal

Ginekologia Polska

Issue

Vol 90, No 1 (2019)

Article type

Research paper

Pages

1-6

Published online

2019-01-31

Page views

2231

Article views/downloads

1521

DOI

10.5603/GP.2019.0001

Pubmed

30756364

Bibliographic record

Ginekol Pol 2019;90(1):1-6.

Keywords

peroxiredoxin-5
ovarian cancer
prognostic factor
overall survival

Authors

Jacek Sienko
Pawel Gaj
Krzysztof Czajkowski
Dominika Nowis

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