open access
Genetic causes of recurrent miscarriages
open access
Abstract
Recurrent miscarriage is an important problem in reproductive health, which affects 1–5% of couples. The aim of this article is to summarize current knowledge on the genetic causes of recurrent miscarriage. It presents the most common parental genetic disorders (karyotype abnormalities, recessive diseases carrier status, dominant diseases and thrombophilia) connected with recurrent pregnancy loss, as well as research into other possible genetic causes. This review also sets out to demonstrate changes in the embryonic/fetal genome that may lead to abortions, and discusses the methods used to assess miscarried material, together with their advantages and disadvantages. Knowledge of the genetic background of miscarriages is important for prognosis, as well as the potential planning of prenatal diagnostics in subsequent pregnancies.
Abstract
Recurrent miscarriage is an important problem in reproductive health, which affects 1–5% of couples. The aim of this article is to summarize current knowledge on the genetic causes of recurrent miscarriage. It presents the most common parental genetic disorders (karyotype abnormalities, recessive diseases carrier status, dominant diseases and thrombophilia) connected with recurrent pregnancy loss, as well as research into other possible genetic causes. This review also sets out to demonstrate changes in the embryonic/fetal genome that may lead to abortions, and discusses the methods used to assess miscarried material, together with their advantages and disadvantages. Knowledge of the genetic background of miscarriages is important for prognosis, as well as the potential planning of prenatal diagnostics in subsequent pregnancies.
Keywords
recurrent miscarriages, chromosome aberrations, genetic causes
About this articleTitle
Genetic causes of recurrent miscarriages
Journal
Issue
Article type
Review paper
Pages
722-726
Published online
2016-10-31
Page views
5044
Article views/downloads
7885
DOI
Pubmed
Bibliographic record
Ginekol Pol 2016;87(10):722-726.
Keywords
recurrent miscarriages
chromosome aberrations
genetic causes
Authors
Marta Kacprzak
Marta Chrzanowska
Beata Skoczylas
Hanna Moczulska
Maciej Borowiec
Piotr Sieroszewski
