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Antenatal corticosteroids and respiratory distress syndrome — the first Polish national survey
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Abstract
Objectives: Our retrospective study aimed to evaluate the rate and the appropriate use of antenatal corticosteroid therapy, and their effect on the incidence and treatment of respiratory distress syndrome (RDS) and its complications.
Material and methods: A retrospective analysis of clinical practice in Poland was performed using standard investigating tools: a questionnaire on the frequency of using antennal corticosteroids in the selected centers, as well as neonatal data. A total of 987 newborns at ≤ 32 weeks of gestation, treated in 54 centers (including 42 tertiary and 12 secondary referral centers) over a period of 6 months in 2013, were deemed eligible. The study group consisted of 749 newborns whose mothers received antenatal steroids. The non-steroid group included 238 newborns.
Results: Antenatal corticosteroids were administered to 75.89% of the neonates from the study group, with 79% and 21% receiving one and two courses, respectively. Children whose mothers received prenatal steroids presented with less extensive radiographic changes typical of RDS, and less often required surfactant therapy (70% vs. 78%; p = 0.0143). In the group of children undergoing antenatal steroid therapy, the percentage of BPD was lower (13.27% vs. 18.63%) (p = 0.0881). The mortality rates were 20.91% and 10.81% in controls and the study group, respectively (p = 0.0001).
Conclusions:
- The percentage of antenatal steroid use in secondary and tertiary referral centers in Poland is unsatisfactorily low (76%).
- Antenatal corticosteroids demonstrated high efficacy in decreasing severe forms of RDS, less need for surfactant therapy, and reduced BPD and mortality rates.
Abstract
Objectives: Our retrospective study aimed to evaluate the rate and the appropriate use of antenatal corticosteroid therapy, and their effect on the incidence and treatment of respiratory distress syndrome (RDS) and its complications.
Material and methods: A retrospective analysis of clinical practice in Poland was performed using standard investigating tools: a questionnaire on the frequency of using antennal corticosteroids in the selected centers, as well as neonatal data. A total of 987 newborns at ≤ 32 weeks of gestation, treated in 54 centers (including 42 tertiary and 12 secondary referral centers) over a period of 6 months in 2013, were deemed eligible. The study group consisted of 749 newborns whose mothers received antenatal steroids. The non-steroid group included 238 newborns.
Results: Antenatal corticosteroids were administered to 75.89% of the neonates from the study group, with 79% and 21% receiving one and two courses, respectively. Children whose mothers received prenatal steroids presented with less extensive radiographic changes typical of RDS, and less often required surfactant therapy (70% vs. 78%; p = 0.0143). In the group of children undergoing antenatal steroid therapy, the percentage of BPD was lower (13.27% vs. 18.63%) (p = 0.0881). The mortality rates were 20.91% and 10.81% in controls and the study group, respectively (p = 0.0001).
Conclusions:
- The percentage of antenatal steroid use in secondary and tertiary referral centers in Poland is unsatisfactorily low (76%).
- Antenatal corticosteroids demonstrated high efficacy in decreasing severe forms of RDS, less need for surfactant therapy, and reduced BPD and mortality rates.
Keywords
antenatal corticosteroids, newborns, RDS, BPD, mortality rate
About this articleTitle
Antenatal corticosteroids and respiratory distress syndrome — the first Polish national survey
Journal
Issue
Article type
Research paper
Pages
498-503
Published online
2016-07-29
Page views
1683
Article views/downloads
2439
DOI
Pubmed
Bibliographic record
Ginekol Pol 2016;87(7):498-503.
Keywords
antenatal corticosteroids
newborns
RDS
BPD
mortality rate
Authors
Maria Katarzyna Borszewska-Kornacka
Ewa Gulczyńska
Marzena Kostuch
Piotr Korbal
Paweł Krajewski
and the Polish Study Group
