Online first
Review paper
Published online: 2023-09-28
The effect of two anti-inflammatory dietary components, omega-3 and resveratrol, on endometriosis
1
, 2, 2, 3, 2, 2
, 2, 2, 3, 2, 2
DOI: 10.5603/gpl.97573
Pubmed: 37768015
Abstract
Endometriosis is an inflammatory condition defined by the presence of endometrial glands and stroma outside the uterine cavity. Given the substantial body of evidence supporting the role of inflammation in the pathophysiology of various chronic illnesses, the concept of an anti-inflammatory diet has garnered significant attention in recent research. Some nutrients, such as omega-3 fatty acids and resveratrol (RES), have demonstrated distinct anti-inflammatory properties. Therefore, the objective of this systematic review was to search the Embase, Medline, and PubMed databases for literature from August 2008 to August 2023 regarding the effects of two anti-inflammatory dietary components, omega-3 and RES, on endometriosis. A total of 215 records were identified, out of which 58 were screened, 23 met the eligibility criteria, and 19 were included in this review. The results of this systematic review indicate that EPA is suggested to have anti-inflammatory properties and may serve as a potential marker for illness severity. RES offers a range of advantages, including inflammation reduction, angiogenesis suppression, proliferation inhibition, and apoptosis induction. To validate these findings and assess their clinical relevance, future research and clinical trials are warranted.
Keywords: endometriosisresveratrolomega-3anti-inflammatory dietpathogenesisdiagnosistreatment
References
- Govindaraju T, Sahle BW, McCaffrey TA, et al. Dietary Patterns and Quality of Life in Older Adults: A Systematic Review. Nutrients. 2018; 10(8).
- Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021; 397(10276): 839–852.
- Zondervan K, Becker C, Missmer S. Endometriosis. New England Journal of Medicine. 2020; 382(13): 1244–1256.
- Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002; 21(6): 495–505.
- Švajger U, Jeras M. Anti-inflammatory effects of resveratrol and its potential use in therapy of immune-mediated diseases. Int Rev Immunol. 2012; 31(3): 202–222.
- Meng Q, Guo T, Li G, et al. Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1. J Anim Sci Biotechnol. 2018; 9: 34.
- Ren B, Kwah MXY, Liu C, et al. Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Lett. 2021; 515: 63–72.
- James M, Gibson R, Cleland L. Dietary polyunsaturated fatty acids and inflammatory mediator production. The American Journal of Clinical Nutrition. 2000; 71(1).
- Hopeman MM, Riley JK, Frolova AI, et al. Serum Polyunsaturated Fatty Acids and Endometriosis. Reprod Sci. 2015; 22(9): 1083–1087.
- Khanaki K, Sadeghi MR, Akhondi MM, et al. High ω-3:ω-6 fatty acids ratio increases fatty acid binding protein 4 and extracellular secretory phospholipase A2IIa in human ectopic endometrial cells. Iran J Reprod Med. 2014; 12(11): 755–764.
- Murakami M, Kudo I. Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prog Lipid Res. 2004; 43(1): 3–35.
- Rizzo MT, Nguyen E, Aldo-Benson M, et al. Secreted phospholipase A(2) induces vascular endothelial cell migration. Blood. 2000; 96(12): 3809–3815.
- Meyer MC, Rastogi P, Beckett CS, et al. Phospholipase A2 inhibitors as potential anti-inflammatory agents. Curr Pharm Des. 2005; 11(10): 1301–1312.
- Khanaki K, Motavalizadeh Ardekani A, Ghassemzadeh A, et al. Effect of polyunsaturated fatty acids on secretory phospholipase A2 type IIa in ectopic endometrial cells. Iran J Reprod Med. 2012; 10(4): 321–328.
- Müller R. Crosstalk of oncogenic and prostanoid signaling pathways. J Cancer Res Clin Oncol. 2004; 130(8): 429–444.
- Boiteux G, Lascombe I, Roche E, et al. A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells. Int J Cancer. 2009; 124(8): 1820–1828.
- Khanaki K, Nouri M, Ardekani AM, et al. Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acids. Iran Biomed J. 2012; 16(1): 38–43.
- Ohlsson G, Moreira JMA, Gromov P, et al. Loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) is associated with progression of human urothelial carcinomas. Mol Cell Proteomics. 2005; 4(4): 570–581.
- McKinnon B, Bersinger NA, Wotzkow C, et al. Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations. Fertil Steril. 2012; 97(2): 373–380.
- Maia H, Haddad C, Pinheiro N, et al. Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain. Int J Womens Health. 2012; 4: 543–549.
- Mendes da Silva D, Gross LA, Neto Ed, et al. The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial. J Endocr Soc. 2017; 1(4): 359–369.
- Nodler JL, DiVasta AD, Vitonis AF, et al. Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2020; 112(1): 229–236.
- Arablou T, Aryaeian N, Khodaverdi S, et al. The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis. Sci Rep. 2021; 11(1): 6054.
- Khodarahmian M, Amidi F, Moini A, et al. A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-α 2 expression in endometriosis women. J Reprod Immunol. 2021; 143: 103248.
- Donnez J, Binda MM, Donnez O, et al. Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis. Fertil Steril. 2016; 106(5): 1011–1017.
- Kolahdouz-Mohammadi R, Shidfar F, Khodaverdi S, et al. Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells. J Cell Mol Med. 2021; 25(2): 1116–1127.
- Khazaei MR, Rashidi Z, Chobsaz F, et al. Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis. Reprod Biol. 2020; 20(4): 484–490.
- Ozawa Y, Murakami T, Tamura M, et al. A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice. Fertil Steril. 2006; 86(4 Suppl): 1146–1151.
- Gołąbek-Grenda A, Kaczmarek M, Juzwa W, et al. Natural resveratrol analogs differentially target endometriotic cells into apoptosis pathways. Sci Rep. 2023; 13(1): 11468.
- Madanes D, Meresman G, Valla SA, et al. Resveratrol impairs cellular mechanisms associated with the pathogenesis of endometriosis. Reprod Biomed Online. 2022; 44(6): 976–990.
- Arablou T, Delbandi AA, Khodaverdi S, et al. Resveratrol reduces the expression of insulin-like growth factor-1 and hepatocyte growth factor in stromal cells of women with endometriosis compared with nonendometriotic women. Phytother Res. 2019; 33(4): 1044–1054.
- Chen Z, Wang C, Lin C, et al. Lipidomic Alterations and PPAR Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models. Oxid Med Cell Longev. 2021; 2021: 9979953.
- Taguchi A, Koga K, Kawana K, et al. Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells. Am J Reprod Immunol. 2016; 75(4): 486–492.
- Kong X, Xu X, Zhou L, et al. MTA1, a Target of Resveratrol, Promotes Epithelial-Mesenchymal Transition of Endometriosis via ZEB2. Mol Ther Methods Clin Dev. 2020; 19: 295–306.
- Sokolov DI, Solodovnikova NG, Pavlov OV, et al. Study of cytokine profile and angiogenic potential of peritoneal fluid in patients with external genital endometriosis. Bull Exp Biol Med. 2005; 140(5): 541–544.
- Yerlikaya G, Balendran S, Pröstling K, et al. Comprehensive study of angiogenic factors in women with endometriosis compared to women without endometriosis. Eur J Obstet Gynecol Reprod Biol. 2016; 204: 88–98.
- Sen N, Gui B, Kumar R. Role of MTA1 in cancer progression and metastasis. Cancer Metastasis Rev. 2014; 33(4): 879–889.
- Kodarahmian M, Amidi F, Moini A, et al. The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial. Gynecol Endocrinol. 2019; 35(8): 719–726.
- Kundu JK, Surh YJ. Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett. 2008; 269(2): 243–261.
- Taguchi A, Wada-Hiraike O, Kawana K, et al. Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: a possible role of the sirtuin 1 pathway. J Obstet Gynaecol Res. 2014; 40(3): 770–778.
