open access
Congenital malformations of the female genital organs
Affiliations- Clinical Department of Gynecology, Obsterics and Subdepartment of Oncological Gynecology, Independent Public Health Care, Kedzierzyn-Kozle, Poland, Poland
- Chair and Department of Gynecology, Obsterics and Oncological Gynecology, Medical University of Silesia in Katowice, Poland
open access
Abstract
Congenital malformations of the female genital organs are rare anomalies and their incidence is estimated to be up to 7% in the general population. Müllerian ducts abnormalities are one of the causes of infertility and occur in approximately 16% of women with recurrent miscarriages. Sex development disorders are diagnosed at different stages of the patient's life depending on the accompanying ailments. Alarming signs of genital malformations include primary amenorrhea or dysmenorrhea, dyspareunia, and periodic abdominal pain.
Abstract
Congenital malformations of the female genital organs are rare anomalies and their incidence is estimated to be up to 7% in the general population. Müllerian ducts abnormalities are one of the causes of infertility and occur in approximately 16% of women with recurrent miscarriages. Sex development disorders are diagnosed at different stages of the patient's life depending on the accompanying ailments. Alarming signs of genital malformations include primary amenorrhea or dysmenorrhea, dyspareunia, and periodic abdominal pain.
Keywords
congenital malformations; female genital; uterine septum; mayer-rokitansky-kűster-hauser; androgen insensitivity syndrome syndrome; ohvira syndrome
About this articleTitle
Congenital malformations of the female genital organs
Journal
Issue
Article type
Review paper
Published online
2024-01-22
Page views
205
Article views/downloads
219
DOI
Pubmed
Keywords
congenital malformations
female genital
uterine septum
mayer-rokitansky-kűster-hauser
androgen insensitivity syndrome syndrome
ohvira syndrome
Authors
Wiktoria Klimanek
Agnieszka Drosdzol-Cop
References (22)- Passos Id, Britto RL. Diagnosis and treatment of müllerian malformations. Taiwan J Obstet Gynecol. 2020; 59(2): 183–188.
- Yadav G, Agrawal N, Binit S, et al. Transverse vaginal septum presenting as secondary amenorrhoea: a rare clinical presentation. BMJ Case Rep. 2020; 13(8).
- Kaur P, Panneerselvam D. Bicornuate Uterus. StatPearls May 15, 2023.
- Barut A, Hirsi ZA, Yusuf K. Management of an isolated complete imperforate transverse vaginal septum: A case report. Int J Surg Case Rep. 2022; 100: 107744.
- Abdelrahman H, Feloney M. Imperforate Hymen. StatPearlsuly July 11, 2022.
- Carbonnel M, Pirtea P, Ziegler Dde, et al. Uterine factors in recurrent pregnancy losses. Fertility and Sterility. 2021; 115(3): 538–545.
- Noventa M, Spagnol G, Marchetti M, et al. Uterine Septum with or without Hysteroscopic Metroplasty: Impact on Fertility and Obstetrical Outcomes—A Systematic Review and Meta-Analysis of Observational Research. Journal of Clinical Medicine. 2022; 11(12): 3290.
- Rikken J, Kowalik CR, Emanuel MH, et al. Septum resection versus expectant management in women with a septate uterus: an international multicentre open-label randomized controlled trial. Human Reproduction. 2021; 36(5): 1260–1267.
- Rikken JFW, Verhorstert KWJ, Emanuel MH, et al. Septum resection in women with a septate uterus: a cohort study. Hum Reprod. 2020; 35(7): 1578–1588.
- Gulavi E, Kyende Mutiso S, Mariara Muriuki C, et al. Successful Pregnancy Outcome after Open Strassman Metroplasty for Bicornuate Uterus. Case Rep Obstet Gynecol. 2018; 2018: 4579736.
- Zhang C, Wang X, Jiang H, et al. Placenta percreta after Strassman metroplasty of complete bicornuate uterus: a case report. BMC Pregnancy Childbirth. 2021; 21(1): 95.
- Tellum T, Bracco B, De Braud LV, et al. Reproductive outcome in 326 women with unicornuate uterus. Ultrasound Obstet Gynecol. 2023; 61(1): 99–108.
- Ma YC, Law KS. Pregnancy in a Non-Communicating Rudimentary Horn of Unicornuate Uterus. Diagnostics (Basel). 2022; 12(3).
- Crowley CM, Botros K, Hegazy IF, et al. Uterine didelphys: diagnosis, management and pregnancy outcome. BMJ Case Rep. 2021; 14(3).
- Samanta A, Rahman SM, Vasudevan A, et al. A novel combination of OHVIRA syndrome and likely causal variant in UMOD gene. CEN Case Rep. 2023; 12(2): 249–253.
- Herlin M, Petersen M, Brännström M. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: a comprehensive update. Orphanet Journal of Rare Diseases. 2020; 15(1).
- Bjørsum-Meyer T, Herlin M, Qvist N, et al. Vertebral defect, anal atresia, cardiac defect, tracheoesophageal fistula/esophageal atresia, renal defect, and limb defect association with Mayer-Rokitansky-Küster-Hauser syndrome in co-occurrence: two case reports and a review of the literature. J Med Case Rep. 2016; 10(1): 374.
- Bjørsum-Meyer T, Herlin M, Qvist N, et al. Vertebral defect, anal atresia, cardiac defect, tracheoesophageal fistula/esophageal atresia, renal defect, and limb defect association with Mayer-Rokitansky-Küster-Hauser syndrome in co-occurrence: two case reports and a review of the literature. J Med Case Rep. 2016; 10(1): 374.
- Avino A, Răducu L, Tulin A, et al. Vaginal Reconstruction in Patients with Mayer-Rokitansky-Küster-Hauser Syndrome-One Centre Experience. Medicina (Kaunas). 2020; 56(7).
- Batista RL, Costa EM, Rodrigues Ad, et al. Androgen insensitivity syndrome: a review. Arch Endocrinol Metab. 2018; 62(2): 227–235.
- Xiao X, Zhou Y. Complete androgen insensitivity Syndrome: A rare case report. Asian Journal of Surgery. 2023: S1015-9584(23)00651-6.
- Barros B, Oliveira L, Surur C, et al. Complete androgen insensitivity syndrome and risk of gonadal malignancy: systematic review. Annals of Pediatric Endocrinology & Metabolism. 2021; 26(1): 19–23.
