Vol 93, No 9 (2022)
Review paper
Published online: 2022-08-16
Anti-Mullerian hormone levels in girls and adolescents
Abstract
Anti-Mullerian hormone (AMH) is a homodimeric glycoprotein which belongs to the TGF-beta superfamily of growth and differentiation factors. There are few studies that present AMH concentrations in premenarcheal and early postmenarcheal girls. The aim of this study is to evaluate AMH levels in girls. A serum AMH increase of 1 pmol/L is related with a higher possibility of menarche occurrence. AMH levels are significantly higher in postmenarcheal girls than in prepubertal girls.
Keywords: Anti-Mullerian hormonepubertyadolescentspediatric endocrinology
References
- Josso N, Rey RA, Picard JY. Anti-müllerian hormone: a valuable addition to the toolbox of the pediatric endocrinologist. Int J Endocrinol. 2013; 2013: 674105.
- Özcan P, Fiçicioğlu C, Ateş S, et al. The cutoff values of serum AMH levels and starting recFSH doses for the individualization of IVF treatment strategies. Gynecol Endocrinol. 2017; 33(6): 467–471.
- Hagen CP, Aksglaede L, Sørensen K, et al. Serum levels of anti-Müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients. J Clin Endocrinol Metab. 2010; 95(11): 5003–5010.
- Codner E, Iñiguez G, Hernández IM, et al. Elevated anti-Müllerian hormone (AMH) and inhibin B levels in prepubertal girls with type 1 diabetes mellitus. Clin Endocrinol (Oxf). 2011; 74(1): 73–78.
- Kelsey TW, Wright P, Nelson SM, et al. A validated model of serum anti-müllerian hormone from conception to menopause. PLoS One. 2011; 6(7): e22024.
- Kelsey TW, Anderson RA, Wright P, et al. Data-driven assessment of the human ovarian reserve. Mol Hum Reprod. 2012; 18(2): 79–87.
- Hagen CP, Aksglaede L, Sørensen K, et al. Individual serum levels of anti-Müllerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study. Hum Reprod. 2012; 27(3): 861–866.
- Lee MM, Donahoe PK, Hasegawa T, et al. Mullerian inhibiting substance in humans: normal levels from infancy to adulthood. J Clin Endocrinol Metab. 1996; 81(2): 571–576.
- Ortega MT, Carlson L, McGrath JA, et al. AMH is Higher Across the Menstrual Cycle in Early Postmenarchal Girls than in Ovulatory Women. J Clin Endocrinol Metab. 2020; 105(4).
- Elchuri SV, Patterson BC, Brown MR, et al. Anti-Mullerian hormone levels in American girls by age and race/ethnicity. J Pediatr Endocrinol Metab. 2015; 28(1-2): 189–193.
- Sahin NM, Kinik ST, Tekindal MA, et al. AMH levels at central precocious puberty and premature thelarche: is it a parameter? J Pediatr Endocrinol Metab. 2015; 28(11-12): 1351–1356.
- Chen T, Wu H, Xie R, et al. Serum Anti-Müllerian Hormone and Inhibin B as Potential Markers for Progressive Central Precocious Puberty in Girls. J Pediatr Adolesc Gynecol. 2017; 30(3): 362–366.
- Efthymiadou A, Bogiatzidou M, Kritikou D, et al. Anti-Müllerian Hormone in Girls with Premature Adrenarche: The Impact of Polycystic Ovary Syndrome History in their Mothers. J Pediatr. 2019; 205: 190–194.
- Utriainen P, Jääskeläinen J, Voutilainen R. Serum anti-müllerian hormone concentrations in prepubertal girls with and without premature adrenarche: The influence of body mass index. Horm Res Paediatr. 2010; 74(3): 207–211.
- Savas-Erdeve S, Sagsak E, Keskin M, et al. AMH levels in girls with various pubertal problems. J Pediatr Endocrinol Metab. 2017; 30(3): 333–335.