Vol 93, No 11 (2022)
Research paper
Published online: 2022-02-10

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Relationship of cystatin C, Hs-CRP, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with isolated oligohydramnios

Ozlem Erten1, Aysun Tekeli Taskomur2
Pubmed: 35156694
Ginekol Pol 2022;93(11):881-888.

Abstract

Objectives: We evaluated inflammatory parameters in pregnant women with isolated oligohydramnios.

Material and methods: This prospective cross-sectional study enrolled 54 pregnant with isolated oligohydramnios (IO) and 54 matched by gestational week, healthy pregnant with normal amniotic fluid. Maternal plasma levels of cystatin C, hs-CRP, neutrophil-lymphocyte ratios (NLR), platelet-lymphocyte ratios (PLR), and pregnancy outcomes were compared between two groups.

Results: Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than that in the control group (p < 0.05). In the IO group, the rate of primary cesarean section, fetal distress, neonates with meconium-stained, and need for neonatal intensive care unit was higher, and Apgar scores were significantly lower than those in the control group (p < 0.05). There was no significant difference between the groups for meconium-stained neonate rates and the intensive care unit’s need in the late-term (410/7–416/7 weeks). Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than the control group (p < 0.05). Cystatin C was positively correlated with the need for neonatal intensive care and negatively correlated with Apgar scores. The PLR was positively correlated with the rate of meconium-stained neonates (p < 0.05). Cystatin C and hs-CRP had significant value in predicting IO (p < 0.05).

Conclusions: Maternal serum levels of Cystatin C and hs-CRP may support the diagnosis and prediction of perinatal
outcomes as possible biochemical markers in IO cases. In particular, a high level of cystatin C may indicate the need
for neonatal intensive care and low Apgar scores. In addition, late-term IO may show similar results in meconium
and neonatal intensive care needs compared to without oligohydramnios.

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