Vol 92, No 10 (2021)
Clinical vignette
Published online: 2021-09-27

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Hyperthyroidism secondary to a hydatidiform mole

Barbara Grzechocinska1, Malgorzata Gajewska1, Maciej Kedzierski1, Sylwia Gajda2, Piotr Jedrzejak1, Miroslaw Wielgos1
Pubmed: 34747003
Ginekol Pol 2021;92(10):741-742.


The case presented in the article is that of a 47-year-old female patient with hyperthyroidism induced by a hydatidiform mole. Attention was drawn to the necessity of preparing the patient for a procedure with drugs that stabilize the hormonal activity of the thyroid. The removal of the hydatidiform mole resulted in gradual normalization of thyroid hormone levels.
The trophoblast has a hormonal activity, secrete hCG (human chorionic gonadotropin).The hCG partial structural homology causes affinity to the TSH (thyroid stimulating hormone) receptor. The higher the weight of the trophoblast, the higher the production and concentration of hCG in the blood.
Therefore, gestational trophoblastic disease may be accompanied by hyperthyroidism. The problem is frequently described, however, due to the risk of developing thyroid storm, it cannot be overlooked [1].

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