open access
Prediction of preterm birth using PAMG-1 test: a single centre experience — preliminary report
- Clinical Department of Perinatology, Gynaecology and Obstetrics in Ruda Slaska, Medical University of Silesia, Ruda Slaska, Poland, Poland
open access
Abstract
Objectives: Placental alpha microglobulin-1 (PAMG-1) is a novel biomarker detected in cervicovaginal discharge in patients threatened with preterm birth (PTB). This study aimed to show a single centre experience of assessment of imminent spontaneous PTB risk in patients with symptoms suggesting preterm labour (PTL).
Material and methods: The study group consisted of 46 women with singleton pregnancies between 24 + 0/7 and 33 + 6/7 weeks of gestation who presented with symptoms of threatened PTL, with cervical dilatation of < 3 cm, cervical length (CL) of < 30 mm and clinically intact fetal membranes. CL was measured via transvaginal ultrasound and the PAMG-1 test was performed in all of the objectives.
Results: Sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of prediction of PTB within seven days for CL were 100%, 11.11%, 5.88% and 100%, respectively. The PAMG-1 test SN, SP, PPV and NPV of the same endpoint were 50%, 80.56%, 12.5% and 96.67%, respectively.
Conclusions: PAMG-1 is a more accurate predictor of PTB when compared to CL. Routine use of both mentioned tests could allow identification of low-risk patients and reduction of rate of unnecessary hospitalizations and treatments.
Abstract
Objectives: Placental alpha microglobulin-1 (PAMG-1) is a novel biomarker detected in cervicovaginal discharge in patients threatened with preterm birth (PTB). This study aimed to show a single centre experience of assessment of imminent spontaneous PTB risk in patients with symptoms suggesting preterm labour (PTL).
Material and methods: The study group consisted of 46 women with singleton pregnancies between 24 + 0/7 and 33 + 6/7 weeks of gestation who presented with symptoms of threatened PTL, with cervical dilatation of < 3 cm, cervical length (CL) of < 30 mm and clinically intact fetal membranes. CL was measured via transvaginal ultrasound and the PAMG-1 test was performed in all of the objectives.
Results: Sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of prediction of PTB within seven days for CL were 100%, 11.11%, 5.88% and 100%, respectively. The PAMG-1 test SN, SP, PPV and NPV of the same endpoint were 50%, 80.56%, 12.5% and 96.67%, respectively.
Conclusions: PAMG-1 is a more accurate predictor of PTB when compared to CL. Routine use of both mentioned tests could allow identification of low-risk patients and reduction of rate of unnecessary hospitalizations and treatments.
Keywords
preterm birth, preterm labou; placental alpha microglobulin-1 (PAMG-1); PartoSure; cervical length (CL)
Title
Prediction of preterm birth using PAMG-1 test: a single centre experience — preliminary report
Journal
Issue
Article type
Research paper
Pages
574-577
Published online
2021-11-23
Page views
4669
Article views/downloads
709
DOI
Pubmed
Bibliographic record
Ginekol Pol 2022;93(7):574-577.
Keywords
preterm birth
preterm labou
placental alpha microglobulin-1 (PAMG-1)
PartoSure
cervical length (CL)
Authors
Wojciech Cnota
Agnieszka Jagielska
Ewa Janowska
Ewa Banas
Rafal Kierach
Malgorzata Nycz-Reska
Bartosz Czuba
- Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012; 379(9832): 2162–2172.
- Althabe F, Howson CP, Kinney M. World Health Organization Born too soon: the global action report on preterm birth. 2012.
- WARD R. Neonatal complications following preterm birth. BJOG: An International Journal of Obstetrics and Gynaecology. 2003; 110: 8–16.
- Koullali B, Oudijk MA, Nijman TAJ, et al. Risk assessment and management to prevent preterm birth. Semin Fetal Neonatal Med. 2016; 21(2): 80–88.
- Sanchez-Ramos L, Delke I, Zamora J, et al. Fetal fibronectin as a short-term predictor of preterm birth in symptomatic patients. Obstetric Anesthesia Digest. 2010; 30(4): 214–215.
- Sotiriadis A, Papatheodorou S, Kavvadias A, et al. Transvaginal cervical length measurement for prediction of preterm birth in women with threatened preterm labor: a meta-analysis. Ultrasound Obstet Gynecol. 2010; 35(1): 54–64.
- Empana JP, Anceschi MM, Szabo I, et al. EURAIL Study Group. Antenatal corticosteroids policies in 14 European countries: factors associated with multiple courses. The EURAIL survey. Acta Paediatr. 2004; 93(10): 1318–1322.
- Peltoniemi OM, Kari MA, Tammela O, et al. Repeat Antenatal Betamethasone Study Group. Randomized trial of a single repeat dose of prenatal betamethasone treatment in imminent preterm birth. Pediatrics. 2007; 119(2): 290–298.
- Dunlop S, Archer M, Quinlivan J, et al. Repeated prenatal corticosteroids delay myelination in the ovine central nervous system. Journal of Maternal-Fetal and Neonatal Medicine. 1997; 6(6): 309–313.
- Nikolova T, Bayev O, Nikolova N, et al. Evaluation of a novel placental alpha microglobulin-1 (PAMG-1) test to predict spontaneous preterm delivery. J Perinat Med. 2014; 42(4): 473–477.
- Nikolova T, Bayev O, Nikolova N, et al. Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor. J Perinat Med. 2015; 43(4): 395–402.
- Lee SMi, Romero R, Park JW, et al. The clinical significance of a positive Amnisure test in women with preterm labor and intact membranes. J Matern Fetal Neonatal Med. 2012; 25(9): 1690–1698.
- Tripathi R, Tyagi S, Mala YM, et al. Comparison of rapid bedside tests for phosphorylated insulin-like growth factor-binding protein 1 and fetal fibronectin to predict preterm birth. Int J Gynaecol Obstet. 2016; 135(1): 47–50.
- Cooper S, Lange I, Wood S, et al. Diagnostic accuracy of rapid phIGFBP-I assay for predicting preterm labor in symptomatic patients. J Perinatol. 2012; 32(6): 460–465.
- Bolotskikh V, Borisova V. Combined value of placental alpha microglobulin-1 detection and cervical length via transvaginal ultrasound in the diagnosis of preterm labor in symptomatic patients. J Obstet Gynaecol Res. 2017; 43(8): 1263–1269.
- Lucovnik M, Chambliss LR, Garfield RE. Costs of unnecessary admissions and treatments for "threatened preterm labor". Am J Obstet Gynecol. 2013; 209(3): 217.e1–217.e3.
- Melchor JC, Khalil A, Wing D, et al. Prediction of preterm delivery in symptomatic women using PAMG-1, fetal fibronectin and phIGFBP-1 tests: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018; 52(4): 442–451.