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Research paper
Published online: 2021-05-26
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Role of platelet indices in prediction of preeclampsia

Muzaffer Temur1, Fatma Nurgül Taşgöz2, Tayfur Çift2, Gülçin Serpim3, Emin Üstünyurt2
DOI: 10.5603/GP.a2021.0056
·
Pubmed: 34105753
Affiliations
  1. Bursa Yıldırım Special Doruk Hospital, Bursa, Turkey
  2. HSU Bursa Yüksek İhtisas Training and Research Hospital, Bursa Yüksek İhtisas Eğitim ve araştırma Hastanesi Mimar sina mah emniyet cad yıldırım, Bursa, Turkey
  3. Yozgat City Hospital Department of Obstetrics and Gynecology, Yozgat, Turkey

open access

Ahead of Print
ORIGINAL PAPERS Obstetrics
Published online: 2021-05-26

Abstract

Objectives: To compare platelet indices in preeclamptic and normotensive pregnants and to investigate the clinical use of these parameters in preeclampsia prediction.

Material and methods: This retrospective case- control study included 257 preeclampsia patients and 264 healthy pregnant women as the control group. The groups were compared in terms of platelet count (PC), mean platelet volume (MPV), platelet distribution range (PDW), plateletcrit (Pct), Pct / MPV ratio and PC / MPV ratio.

Results: Between the preeclampsia group and the control group; mean platelet count (227.22 ± 78.58 vs 236.69 ± 64.30), plateletcrit (PCT) (0.21 ± 0.06 vs 0.24 ± 0.27), and platelet distribution width (PDW) (17.11 ± 0.80 vs 17.29 ± 0.82) were not significantly different (p> 0.05). However, MPV values ​​were significantly higher in the preclampsia group compared to the control group (9.66 ± 1.62 and 8.92 ± 1.33, respectively) (p < 0.001). In our study, the optimum cut-off value of MPV was 9.15 with 58.7% sensitivity and 61.7% specificity for the prediction of preeclampsia. Pct/MPV ratio (0.02 ± 0.007 vs 0.027 ± 0.029) ( p = 0.01) and PC/MPV ratio ( 24.63 ± 10.90 vs 27.63 ± 10.24) (p = 0.001) were significantly lower in the preeclampsia group than in the control group.

Conslusions: In preeclampsia, changes in platelet functions, destruction and production lead to changes in platelet indices. Compared with normal healthy pregnant women, preeclamptic pregnant women have higher MPV values. In preeclampsia prediction, MPV and PC/MPV ratio are promising as a diagnostic parameter.

Abstract

Objectives: To compare platelet indices in preeclamptic and normotensive pregnants and to investigate the clinical use of these parameters in preeclampsia prediction.

Material and methods: This retrospective case- control study included 257 preeclampsia patients and 264 healthy pregnant women as the control group. The groups were compared in terms of platelet count (PC), mean platelet volume (MPV), platelet distribution range (PDW), plateletcrit (Pct), Pct / MPV ratio and PC / MPV ratio.

Results: Between the preeclampsia group and the control group; mean platelet count (227.22 ± 78.58 vs 236.69 ± 64.30), plateletcrit (PCT) (0.21 ± 0.06 vs 0.24 ± 0.27), and platelet distribution width (PDW) (17.11 ± 0.80 vs 17.29 ± 0.82) were not significantly different (p> 0.05). However, MPV values ​​were significantly higher in the preclampsia group compared to the control group (9.66 ± 1.62 and 8.92 ± 1.33, respectively) (p < 0.001). In our study, the optimum cut-off value of MPV was 9.15 with 58.7% sensitivity and 61.7% specificity for the prediction of preeclampsia. Pct/MPV ratio (0.02 ± 0.007 vs 0.027 ± 0.029) ( p = 0.01) and PC/MPV ratio ( 24.63 ± 10.90 vs 27.63 ± 10.24) (p = 0.001) were significantly lower in the preeclampsia group than in the control group.

Conslusions: In preeclampsia, changes in platelet functions, destruction and production lead to changes in platelet indices. Compared with normal healthy pregnant women, preeclamptic pregnant women have higher MPV values. In preeclampsia prediction, MPV and PC/MPV ratio are promising as a diagnostic parameter.

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Keywords

mean platelet volume; platelet count; preeclampsia

About this article
Title

Role of platelet indices in prediction of preeclampsia

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-05-26

DOI

10.5603/GP.a2021.0056

Pubmed

34105753

Keywords

mean platelet volume
platelet count
preeclampsia

Authors

Muzaffer Temur
Fatma Nurgül Taşgöz
Tayfur Çift
Gülçin Serpim
Emin Üstünyurt

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