open access

Vol 92, No 7 (2021)
Research paper
Published online: 2021-03-30
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Different modes of delivery and hormonal stress response

Magdalena Bulska1, Piotr Szczesniak2, Agnieszka Pieta-Dolinska3, Patrycja Dorobek2, Jolanta Parafiniuk3, Przemyslaw Oszukowski3, Daria Orszulak-Michalak2
DOI: 10.5603/GP.a2021.0068
·
Pubmed: 33844248
·
Ginekol Pol 2021;92(7):481-486.
Affiliations
  1. Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical University of Lodz,, Poland
  2. Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Poland
  3. Gynecology and Obstetrics Ward, Maria Skłodowska-Curie Memorial Provincial Specialist Hospital in Zgierz, Poland

open access

Vol 92, No 7 (2021)
ORIGINAL PAPERS Gynecology
Published online: 2021-03-30

Abstract

Objectives: The aim of the study was to determine how the type of delivery affects the stress response cycle and the level of cortisol, progesterone and corticoliberin.
Material and methods: The study was conducted among 26 pregnant women admitted to the Gynecology and Obstetrics Ward due to an approaching delivery date or the onset of labor. The participants were aged between 20 and 41 years, with a mean age of approximately 30 years. After delivery, blood was drawn in parallel from the maternal antecubital vein, the umbilical cord vein and the umbilical cord artery. The levels of stress hormones were assessed by ELISA. The results were subjected to statistical analyses, and correlation coefficients were calculated for individual variable pairs. The analysis also examined the participation of pregnant woman in antenatal education.
Results: A high correlation was observed between cortisol and progesterone levels in venous and arterial cord blood and physiological delivery. The mean cortisol level was 247.37 ng/mL in venous cord blood and 233.59 ng/mL in arterial blood and the respective mean progesterone levels were 331.81 ng/mL and 342.36 ng/mL. The highest cortisol concentration was determined in the primiparas umbilical cord blood (236.182 ng/mL in the vein, 230.541 ng/mL in the artery). Correlation between cortisol level in venous and arterial cord blood and prenatal education was also noted (venous cord blood: r = –0.5477; F = 10.2833; p = 0.0038; cord arterial blood: r = –0, 4436; F = 5.8789; p = 0.0232).
Conclusions: The results obtained emphasize the importance of the hypothalamic-pituitary-adrenal (HPA) axis as one of the potential mechanisms actively involved in childbirth. The determined levels of cortisol and progesterone in the maternal and umbilical cord blood varied significantly depending on the type of delivery, with higher concentrations being observed in the case of natural delivery. In addition, the highest levels of cortisol were determined in primiparas; however, lowered umbilical cord blood cortisol levels were observed in pregnant women who had participated in antenatal education, regardless of the number of deliveries.

Abstract

Objectives: The aim of the study was to determine how the type of delivery affects the stress response cycle and the level of cortisol, progesterone and corticoliberin.
Material and methods: The study was conducted among 26 pregnant women admitted to the Gynecology and Obstetrics Ward due to an approaching delivery date or the onset of labor. The participants were aged between 20 and 41 years, with a mean age of approximately 30 years. After delivery, blood was drawn in parallel from the maternal antecubital vein, the umbilical cord vein and the umbilical cord artery. The levels of stress hormones were assessed by ELISA. The results were subjected to statistical analyses, and correlation coefficients were calculated for individual variable pairs. The analysis also examined the participation of pregnant woman in antenatal education.
Results: A high correlation was observed between cortisol and progesterone levels in venous and arterial cord blood and physiological delivery. The mean cortisol level was 247.37 ng/mL in venous cord blood and 233.59 ng/mL in arterial blood and the respective mean progesterone levels were 331.81 ng/mL and 342.36 ng/mL. The highest cortisol concentration was determined in the primiparas umbilical cord blood (236.182 ng/mL in the vein, 230.541 ng/mL in the artery). Correlation between cortisol level in venous and arterial cord blood and prenatal education was also noted (venous cord blood: r = –0.5477; F = 10.2833; p = 0.0038; cord arterial blood: r = –0, 4436; F = 5.8789; p = 0.0232).
Conclusions: The results obtained emphasize the importance of the hypothalamic-pituitary-adrenal (HPA) axis as one of the potential mechanisms actively involved in childbirth. The determined levels of cortisol and progesterone in the maternal and umbilical cord blood varied significantly depending on the type of delivery, with higher concentrations being observed in the case of natural delivery. In addition, the highest levels of cortisol were determined in primiparas; however, lowered umbilical cord blood cortisol levels were observed in pregnant women who had participated in antenatal education, regardless of the number of deliveries.

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Keywords

physiological delivery; cesarean section; stress hormones; cortisol; progesterone; corticoliberin

About this article
Title

Different modes of delivery and hormonal stress response

Journal

Ginekologia Polska

Issue

Vol 92, No 7 (2021)

Article type

Research paper

Pages

481-486

Published online

2021-03-30

DOI

10.5603/GP.a2021.0068

Pubmed

33844248

Bibliographic record

Ginekol Pol 2021;92(7):481-486.

Keywords

physiological delivery
cesarean section
stress hormones
cortisol
progesterone
corticoliberin

Authors

Magdalena Bulska
Piotr Szczesniak
Agnieszka Pieta-Dolinska
Patrycja Dorobek
Jolanta Parafiniuk
Przemyslaw Oszukowski
Daria Orszulak-Michalak

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  10. Löfgren M, Bäckström T. High progesterone is related to effective human labor. Study of serum progesterone and 5alpha-pregnane-3,20-dione in normal and abnormal deliveries. Acta Obstet Gynecol Scand. 1997; 76(5): 423–430.
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