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Vol 92, No 1 (2021)
Review paper
Published online: 2021-01-29
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Metformin administration during pregnancy — current insight

Milena Skibinska12, Monika Zurawska- Klis2, Michal Krekora1, Katarzyna Cypryk2
DOI: 10.5603/GP.a2020.0149
·
Pubmed: 33576490
·
Ginekol Pol 2021;92(1):46-50.
Affiliations
  1. Department of Obstetrics and Gynecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland
  2. Department of Internal Diseases and Diabetology, Central Clinical Hospital of The Medical University, Lodz, Poland, Poland

open access

Vol 92, No 1 (2021)
REVIEW PAPERS Obstetrics
Published online: 2021-01-29

Abstract

The main mechanism of gestational diabetes mellitus (GDM) is insulin resistance, therefore using metformin as a medicine
reducing insulin resistance appears to be promising.
Currently, the majority of medical associations do not recommend using metformin during pregnancy as the first-line of
therapy when the diet regimen is insufficient for glycaemic control. However, they do allow its administration if there is
no possibility of insulin treatment.
There is some evidence which suggests that using metformin during pregnancy is not related to an increased risk of obstetric
complications during delivery and that its influence on the foetus can be beneficial.
Since metformin crosses the placenta, the major argument for cautious use of this drug are the potential long-term effects
of the treatment for the child and its development in later life.
In this article, the authors attempt to discuss the use of metformin during pregnancy and the safety of the treatment in
the light of current studies and recommendations.

Abstract

The main mechanism of gestational diabetes mellitus (GDM) is insulin resistance, therefore using metformin as a medicine
reducing insulin resistance appears to be promising.
Currently, the majority of medical associations do not recommend using metformin during pregnancy as the first-line of
therapy when the diet regimen is insufficient for glycaemic control. However, they do allow its administration if there is
no possibility of insulin treatment.
There is some evidence which suggests that using metformin during pregnancy is not related to an increased risk of obstetric
complications during delivery and that its influence on the foetus can be beneficial.
Since metformin crosses the placenta, the major argument for cautious use of this drug are the potential long-term effects
of the treatment for the child and its development in later life.
In this article, the authors attempt to discuss the use of metformin during pregnancy and the safety of the treatment in
the light of current studies and recommendations.

Full Text:

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Keywords

metformin; pregnancy; diabetes mellitus; GDM

About this article
Title

Metformin administration during pregnancy — current insight

Journal

Ginekologia Polska

Issue

Vol 92, No 1 (2021)

Article type

Review paper

Pages

46-50

Published online

2021-01-29

Page views

1985

Article views/downloads

2420

DOI

10.5603/GP.a2020.0149

Pubmed

33576490

Bibliographic record

Ginekol Pol 2021;92(1):46-50.

Keywords

metformin
pregnancy
diabetes mellitus
GDM

Authors

Milena Skibinska
Monika Zurawska- Klis
Michal Krekora
Katarzyna Cypryk

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