Expression and significance of Parkinson disease protein 7 in placental, serum and umbilical cord blood in preeclampsia
Abstract
Objectives: To study the role of changes in the expression of human Parkinson’s disease protein 7 (PARK7/DJ-1) in preeclampsia.
Material and methods: We selected 120 gravidas, including 60 cases of severe preeclampsia group and control group, and
divided into early onset preeclampsia group (< 34 weeks), late onset preeclampsia group (≥ 34 weeks) and control group
according to the onset of pregnancy. The expression level of DJ-1 was detected by ELISA. The expression level of DJ-1 in
placenta tissue of gravidas was detected by Western-blot and RT-PCR.
Results: The level of DJ-1 in serum and cord blood of preeclampsia group was higher than that of control group. The relative
level of DJ-1 protein and DJ-1 mRNA in placenta tissue of preeclampsia group was higher than that of control group.
Conclusions: The expression level of DJ-1 in serum, umbilical cord blood and placenta tissue increased in preeclampsia
patients, suggesting that DJ-1 may take part in the pathophysiology process of preeclampsia.
Keywords: DJ-1preeclampsiaplacentacord bloodoxidative stress
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