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Nasal bone in screening for Trisomy 18 and 13 at 11–13 + 6 weeks of gestation — own experiences
Affiliations- Department of Obstetrics and Gynecology in Ruda Slaska, Medical University of Silesia, Ruda Slaska, Poland
- Center for Prenatal Diagnostic, Opole, Poland
- Faculty of Health Sciences, Department of Obstetrics, Nicolaus Copernicus University in Torun, Collegium Medicum, Bydgoszcz, Poland
open access
Abstract
Objectives: The objective of the paper is the suitability assessment of screening for Trisomy 18 and 13 on the basis of NT
measurement, FHR, double test and assessment of Nasal Bone.
Material and methods: The study was performed in 6,661 singleton pregnancies. In each fetus NT, FHR, DV-PIV were
examined. Double test from maternal blood was examined. These ultrasound and biochemical factors were in combined
screening investigated. Additional ultrasound marker — Nasal Bone was and its impact on Trisomies 18 and 13 screening
was examined.
Results: Two groups of patients were compared — with chromosomal normal and chromosomal abnormalities — Trisomy
18 and 13. Detection Rate of Trisomies 18 and 13 at the risk cutoff 1/300 using combined screening was 84.1% and FPR
was 7.1%. Detection Rates of examined chromosomal abnormalities using screening with additional marker — NB was
93.2% and False Positive Rate — 5.6%.
Conclusions: It should be noted that the qualitative analysis of the assessment of NB in the first trimester significantly
influences the improvement of screening values focusing on Trisomy 18 and 13 detection. In summary, our research indicates
a more effective type of Trisomy 13 and 18 screening using NT, double test, maternal age, CRL and FHR as well as
nasal bone presence and absence.
Abstract
Objectives: The objective of the paper is the suitability assessment of screening for Trisomy 18 and 13 on the basis of NT
measurement, FHR, double test and assessment of Nasal Bone.
Material and methods: The study was performed in 6,661 singleton pregnancies. In each fetus NT, FHR, DV-PIV were
examined. Double test from maternal blood was examined. These ultrasound and biochemical factors were in combined
screening investigated. Additional ultrasound marker — Nasal Bone was and its impact on Trisomies 18 and 13 screening
was examined.
Results: Two groups of patients were compared — with chromosomal normal and chromosomal abnormalities — Trisomy
18 and 13. Detection Rate of Trisomies 18 and 13 at the risk cutoff 1/300 using combined screening was 84.1% and FPR
was 7.1%. Detection Rates of examined chromosomal abnormalities using screening with additional marker — NB was
93.2% and False Positive Rate — 5.6%.
Conclusions: It should be noted that the qualitative analysis of the assessment of NB in the first trimester significantly
influences the improvement of screening values focusing on Trisomy 18 and 13 detection. In summary, our research indicates
a more effective type of Trisomy 13 and 18 screening using NT, double test, maternal age, CRL and FHR as well as
nasal bone presence and absence.
Keywords
combined test Trisomy 18 Trisomy 13; first trimester nuchal translucency thickness; Nasal Bone; Serum free β-hCG; Pregnancy-associated plasma protein A
About this articleTitle
Nasal bone in screening for Trisomy 18 and 13 at 11–13 + 6 weeks of gestation — own experiences
Journal
Issue
Article type
Research paper
Pages
256-261
Published online
2020-05-29
Page views
1648
Article views/downloads
1800
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(5):256-261.
Keywords
combined test Trisomy 18 Trisomy 13
first trimester nuchal translucency thickness
Nasal Bone
Serum free β-hCG
Pregnancy-associated plasma protein A
Authors
Bartosz Czuba
Marek Maczka
Wojciech Cnota
Agata Wloch
Agnieszka Jagielska
Anna Niesluchowska-Hoxha
Dariusz Borowski
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