Quantitative and qualitative Ductus Venosus blood flow evaluation in the screening for Trisomy 18 and 13 — suitability study
, 1, 1, 1, 1, 2, 3
Abstract
Objectives: The objective of the paper is the suitability assessment of screening for Trisomy 18 and 13 on the basis of
nuchal translucency (NT) measurement, Fetal Heart Rate (FHR), double test, quantitative [Ductus Venosus (DV) Pulsatility
Index for Veins (PIV)] and qualitative (the A-wave assessment) blood flow evaluation in the DV.
Material and methods: The study was performed in 7296 singleton pregnancies. In each fetus NT, FHR, DV-PIV were
examined. Double test from maternal blood was examined. These ultrasound and biochemical factors were in combined
screening investigated. Additional doppler ultrasound markers such as abnormal a-wave in Ductus Venosus and Pusatility
Index for Veins of Ductus Venosus were and their impact on Trisomies 18 and 13 screening were examined.
Results: Two groups of patients were compared — with chromosomal normal and chromosomal abnormalities — Trisomy
18 and 13. Detection Rate of Trisomies 18 and 13 at the risk cutoff 1/300 using combined screening was 90.2% and FPR was
6%. Detection Rates of examined chromosomal abnormalities using contingent screening were: 92.1% using DV abnormal
a-wave and 94.84% using DV-PIV. FPR’s for booths parameters 5.8% and 5.4% respectively.
Conclusions: Quantitative analysis of the flow — assessment of DV-PIV in the first trimester significantly influences the
improvement of screening values focusing on Trisomy 18 and 13 detection.
Keywords: Combined test trisomy 18 trisomy 13first trimester nuchal translucency thicknessductus venosus pulsatility index for veinsserum free β-hcgpregnancy-associated plasma protein A
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