Vol 91, No 4 (2020)
Research paper
Published online: 2020-03-31

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The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting — a prospective study in a tertiary center

Serhat Ege1, Nurullah Peker2, Muhammed Hanifi Bademkıran1, Ruşen Köçeroğlu3, Özcan Erel4, Selami Erdem1, Çağdaş Özgökçe5, Recep Yıldızhan6
Pubmed: 32236936
Ginekol Pol 2020;91(4):207-209.

Abstract

Objectives: We aimed to investigate the thiol/disulfide balance in ketone positive (hyperemesis gravidarum) and ketone
negative pregnant women with nausea and vomiting.
Material and methods: A total of 60 patients under the 14th week of pregnancy were included in this study, and they were
divided into two groups. Group 1 included 30 pregnant women with ketone positive, group 2 included 30 ketone negative
pregnant women with nausea, and vomiting.
Results: The native thiol, disulfide, and total thiol concentrations were measured using an automated method and compared
among the two groups. There were also three indexes that are derived from disulfide, native and total thiol (Index
1 = 100 × disulfide/native thiol); (Index 2 = 100 × disulfide/total thiol); (Index 3 = 100 × native thiol/total thiol). When
compared with Group 1 and Group 2, total thiol was high, native thiol was low but not statistically significant. Disulphide
(p = 0.046), index 1 (p = 0.036) and index 3 (p = 0.034) were statistically significant.
Conclusions: Patients with ketone positive are shifting to OS direction due to lack of nutrients and electrolytes. This study
emphasizes the therapeutic potential of antioxidant supplementation, which is becoming an increasingly used approach
in treating the symptoms of women with ketone positive.

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References

  1. Wijayasinghe S, Bentvelzen A, Guenot C, et al. [Nausea and vomiting in pregnancy]. Rev Med Suisse. 2018; 14(614): 1397–1400.
  2. London V, Grube S, Sherer DM, et al. Hyperemesis Gravidarum: A Review of Recent Literature. Pharmacology. 2017; 100(3-4): 161–171.
  3. Austin K, Wilson K, Saha S. Hyperemesis Gravidarum. Nutr Clin Pract. 2019; 34(2): 226–241.
  4. Fait V, Sela S, Ophir E, et al. Hyperemesis gravidarum is associated with oxidative stress. Am J Perinatol. 2002; 19(2): 93–98.
  5. Fait V, Sela S, Ophir E, et al. Peripheral polymorphonuclear leukocyte priming contributes to oxidative stress in early pregnancy. J Soc Gynecol Investig. 2005; 12(1): 46–49.
  6. Prakash M, Shetty MS, Tilak P, et al. Total Thiols: Biomedical importance and their alteration in various disorders. Online Journal of Health and Allied Sciences. ; 2009.
  7. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem. 2014; 47(18): 326–332.
  8. Biswas S, Chida AS, Rahman I. Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol. 2006; 71(5): 551–564.
  9. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med. 2010; 48(6): 749–762.
  10. Aksoy H, Aksoy AN, Ozkan A, et al. Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum. J Clin Lab Anal. 2009; 23(2): 105–109.
  11. Celik F, Guzel AI, Kuyumcuoglu U, et al. Dietary antioxidant levels in hyperemesis gravidarum: a case control study. Ginekol Pol. 2011; 82(11): 840–844.
  12. van Stuijvenberg ME, Schabort I, Labadarios D, et al. The nutritional status and treatment of patients with hyperemesis gravidarum. Am J Obstet Gynecol. 1995; 172(5): 1585–1591.
  13. Cevrioglu AS, Altindis M, Yilmazer M, et al. Efficient and non-invasive method for investigating Helicobacter pylori in gravida with hyperemesis gravidarum: Helicobacter pylori stool antigen test. J Obstet Gynaecol Res. 2004; 30(2): 136–141.
  14. Onaran Y, Kafali H, Duvan Cİ, et al. Relationship between oxidant and antioxidant activity in hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2014; 27(8): 825–828.
  15. Güney M, Oral B, Mungan T. Serum lipid peroxidation and antioxidant potential levels in hyperemesis gravidarum. Am J Perinatol. 2007; 24(5): 283–289.
  16. Perkins AV. Endogenous anti-oxidants in pregnancy and preeclampsia. Aust N Z J Obstet Gynaecol. 2006; 46(2): 77–83.
  17. Bashiri A, Neumann L, Maymon E, et al. Hyperemesis gravidarum: epidemiologic features, complications and outcome. Eur J Obstet Gynecol Reprod Biol. 1995; 63(2): 135–138.
  18. Ergin M, Cendek BD, Neselioglu S, et al. Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum. J Perinatol. 2015; 35(10): 788–792.
  19. ACOG. Practice Bulletin: nausea and vomiting in pregnancy. Obstetrics and Gynecology. ; 2004.
  20. Ege S, Bademkiran MH, Peker N, et al. Evaluation of catalase, myeloperoxidase and ferroxidase values in pregnant women with hyperemesis gravidarum. Ginekol Pol. 2019; 90(11): 651–655.