Vol 91, No 1 (2020)
Review paper
Published online: 2020-01-31

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Endometrial microbiota — do they mean more than we have expected?

Natalia Mlodzik1, Krzysztof Lukaszuk1, Wlodzimierz Sieg2, Grzegorz Jakiel3, Roman Smolarczyk4
Pubmed: 32039468
Ginekol Pol 2020;91(1):45-48.


Low biomass microbiome has an increasing importance in today’s fertility studies. There are more and more indications
for incorporating upper gynecological tract microbiome content in patients diagnostic and in vitro fertilization process, as
doing so may help to evaluate chances for a positive outcome. An abnormal endometrial microbiota has been associated
with implantation failure, pregnancy loss, and other gynecological and obstetrical conditions. Furthermore it has been
shown, that using molecular methods in addition to routine diagnostics may help diagnose chronic endometritis or even
indicate cancerogenic changes. Understanding the significance of microbiome in endometrium may completely change
therapeutic approach in treatment of this part of reproductive tract. Next generation sequencing (NGS) has allowed to
isolate culturable and unculturable bacteria from female reproductive tract and is a cheaper and quicker alternative for
other widely known and used methods.

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