open access

Vol 90, No 12 (2019)
Review paper
Published online: 2019-12-31
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Coexistence of tooth agenesis and ovarian cancer — a systematic literature review

Weronika Gawron-Jakubek1, Joanna Spaczynska2, Kazimierz Pitynski2, Bartlomiej W. Loster1
·
Pubmed: 31909464
·
Ginekol Pol 2019;90(12):707-710.
Affiliations
  1. Department of Orthodontics, Dental Institute, Faculty of Medicine, Jagiellonian University Medical College, Montelupich St. 4, 31-155 Kraków, Poland
  2. Department of Gynecology and Obstetrics, Faculty of Medicine, Jagiellonian University Medical College, Kopernika St. 23, 32-502 Kraków, Poland

open access

Vol 90, No 12 (2019)
REVIEW PAPERS Gynecology
Published online: 2019-12-31

Abstract

Objectives: Dental agenesis — a congenital lack of teeth — is one of the most frequently diagnosed developmental
defects of dentition. Genetics is a crucial factor in the etiology of this disorder. Missing teeth can be caused by mutation
in genes including MSX1, PAX9, AXIN2, and EDARADD. As is also true for ovarian cancer, over 20% of cases are associated
with hereditary factors. Mutations in the BRCA1 and BRCA2 genes are said to be the most frequent of these. The aim of
this study was to provide a systematic review of the literature on the coexistence of ovarian cancer and tooth agenesis.
Material and methods: Publications were searched for in the online databases PubMed, SCOPUS, and Wiley Online Library.
Current and archival issues of the Journal of Stomatology and Dental and Medical Problems were also searched. The key
words used to find relevant publications were: ovarian cancer, hypodontia, and tooth agenesis, in various combinations.
Results: Three publications were qualified to this review. Two of these compared the incidence of hypodontia in women
with ovarian cancer and in healthy women, and the other was aimed at locating the gene responsible for the coexistence
of ovarian cancer and tooth agenesis. As shown by these studies, women with ovarian cancer are (depending on the study)
3.3 or 8.1 times more likely to have hypodontia than healthy women. However, no specific gene was found that might be
responsible for the coexistence of ovarian cancer and tooth agenesis.

Abstract

Objectives: Dental agenesis — a congenital lack of teeth — is one of the most frequently diagnosed developmental
defects of dentition. Genetics is a crucial factor in the etiology of this disorder. Missing teeth can be caused by mutation
in genes including MSX1, PAX9, AXIN2, and EDARADD. As is also true for ovarian cancer, over 20% of cases are associated
with hereditary factors. Mutations in the BRCA1 and BRCA2 genes are said to be the most frequent of these. The aim of
this study was to provide a systematic review of the literature on the coexistence of ovarian cancer and tooth agenesis.
Material and methods: Publications were searched for in the online databases PubMed, SCOPUS, and Wiley Online Library.
Current and archival issues of the Journal of Stomatology and Dental and Medical Problems were also searched. The key
words used to find relevant publications were: ovarian cancer, hypodontia, and tooth agenesis, in various combinations.
Results: Three publications were qualified to this review. Two of these compared the incidence of hypodontia in women
with ovarian cancer and in healthy women, and the other was aimed at locating the gene responsible for the coexistence
of ovarian cancer and tooth agenesis. As shown by these studies, women with ovarian cancer are (depending on the study)
3.3 or 8.1 times more likely to have hypodontia than healthy women. However, no specific gene was found that might be
responsible for the coexistence of ovarian cancer and tooth agenesis.

Get Citation

Keywords

ovarian cancer; tooth agenesis; hypodontia

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About this article
Title

Coexistence of tooth agenesis and ovarian cancer — a systematic literature review

Journal

Ginekologia Polska

Issue

Vol 90, No 12 (2019)

Article type

Review paper

Pages

707-710

Published online

2019-12-31

Page views

1910

Article views/downloads

1715

DOI

10.5603/GP.2019.0121

Pubmed

31909464

Bibliographic record

Ginekol Pol 2019;90(12):707-710.

Keywords

ovarian cancer
tooth agenesis
hypodontia

Authors

Weronika Gawron-Jakubek
Joanna Spaczynska
Kazimierz Pitynski
Bartlomiej W. Loster

References (34)
  1. Vastardis H. The genetics of human tooth agenesis: New discoveries for understanding dental anomalies. American Journal of Orthodontics and Dentofacial Orthopedics. 2000; 117(6): 650–656.
  2. Schalk van der Weide Y, Prahl-Andersen B, Bosman F. Tooth formation in patients with oligodontia. Angle Orthod. 1993; 63(1): 31–37.
  3. Mattheeuws N. Has hypodontia increased in Caucasians during the 20th century? A meta-analysis. The European Journal of Orthodontics. 2004; 26(1): 99–103.
  4. Polder B, Hof MV, Linden FV, et al. A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dentistry and Oral Epidemiology. 2004; 32(3): 217–226.
  5. Dyras M, Jankowska K, Czupryna S. Ocena częstotliwości występowania zaburzeń rozwojowych zębów u pacjentów leczonych w Katedrze Ortodoncji Instytutu Stomatologii Uniwersytetu Jagiellońskiego. Dent Med Probl. 2003; 40: 349–354.
  6. Baczyk-Łopuch O, Hille A, Loster B. Estimation of hypodontia prevalence in patients treated at the Orthodontic Jagiellonian University Dental Clinic in Cracow. Journal of Stomatology (Czasopismo Stomatologiczne). 2014; 67(5): 624–636.
  7. Parkin N, Elcock C, Smith RN, et al. The aetiology of hypodontia: The prevalence, severity and location of hypodontia within families. Archives of Oral Biology. 2009; 54: S52–S56.
  8. Thesleff I. The genetic basis of tooth development and dental defects. American Journal of Medical Genetics Part A. 2006; 140A(23): 2530–2535.
  9. Bergendal B, Klar J, Stecksén-Blicks C, et al. Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes. American Journal of Medical Genetics Part A. 2011; 155(7): 1616–1622.
  10. Frazier-Bowers SA, Guo DC, Cavender A, et al. A Novel Mutation in HumanPAX9Causes Molar Oligodontia. Journal of Dental Research. 2017; 81(2): 129–133.
  11. Jumlongras D, Lin JY, Chapra A, et al. A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia. Human Genetics. 2004; 114(3): 242–249.
  12. Klein ML, Nieminen P, Lammi L, et al. Novel Mutation of the Initiation Codon of PAX9 Causes Oligodontia. Journal of Dental Research. 2016; 84(1): 43–47.
  13. Mostowska A, Kobielak A, Biedziak B, et al. Novel mutation in the paired box sequence of PAX9 gene in a sporadic form of oligodontia. European Journal of Oral Sciences. 2003; 111(3): 272–276.
  14. Mostowska A, Biedziak B, Trzeciak W. A novel mutation in PAX9 causes familial form of molar oligodontia. European Journal of Human Genetics. 2005; 14(2): 173–179.
  15. Nieminen P, Arte S, Tanner D, et al. Identification of a nonsense mutation in the PAX9 gene in molar oligodontia. European Journal of Human Genetics. 2001; 9(10): 743–746.
  16. Vastardis H, Karimbux N, Guthua S, et al. A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nature Genetics. 1996; 13(4): 417–421.
  17. Boogaard MJv, Dorland M, Beemer F, et al. MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. Nature Genetics. 2000; 24(4): 342–343.
  18. Lidral AC, Reising BC. The Role of MSX1 in Human Tooth Agenesis. Journal of Dental Research. 2016; 81(4): 274–278.
  19. Ogawa T, Kapadia H, Feng J, et al. Functional Consequences of Interactions betweenPax9andMsx1Genes in Normal and Abnormal Tooth Development. Journal of Biological Chemistry. 2006; 281(27): 18363–18369.
  20. Lammi L, Arte S, Somer M, et al. Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer. The American Journal of Human Genetics. 2004; 74(5): 1043–1050.
  21. Mostowska A, Biedziak B, Jagodzinski PP. Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis. J Hum Genet. 2006; 51(3): 262–266.
  22. Krajowy Rejestr Nowotworów. http://onkologia.org.pl (accessed: 30.09.2018).
  23. Lichtenstein P, Holm N, Verkasalo P, et al. Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland. New England Journal of Medicine. 2000; 343(2): 78–85.
  24. Bolton KL, Ganda C, Berchuck A, et al. Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the ovarian cancer association consortium (OCAC). Journal of Internal Medicine. 2012; 271(4): 366–378.
  25. Fekonja A, Čretnik A, Takač I. Hypodontia prevalence and pattern in women with epithelial ovarian cancer. The Angle Orthodontist. 2014; 84(5): 810–814.
  26. Fekonja A, Cretnik A, Zerdoner D, et al. Hypodontia phenotype in patients with epithelial ovarian cancer. Radiology and Oncology. 2015; 49(1): 65–70.
  27. Bonds J, Pollan-White S, Xiang L, et al. Is there a link between ovarian cancer and tooth agenesis? European Journal of Medical Genetics. 2014; 57(5): 235–239.
  28. Iavazzo C, Papakiritsis M, Gkegkes ID. Hypodontia and ovarian cancer: A systematic review. Journal of the Turkish German Gynecological Association. 2016; 17(1): 41–44.
  29. Fekonja A, Cretnik A, Zerdoner D, et al. Hypodontia phenotype in patients with epithelial ovarian cancer. Radiology and Oncology. 2015; 49(1): 65–70.
  30. Küchler EC, Lips A, Tannure PN, et al. Tooth Agenesis Association with Self-reported Family History of Cancer. Journal of Dental Research. 2012; 92(2): 149–155.
  31. Dimova I, Orsetti B, Negre V, et al. Genomic Markers for Ovarian Cancer at Chromosomes 1, 8 and 17 Revealed by Array CGH Analysis. Tumori Journal. 2018; 95(3): 357–366.
  32. Gerber JK, Richter T, Kremmer E, et al. Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. The Journal of Pathology. 2002; 197(3): 293–297.
  33. Muratovska A, Zhou C, He S, et al. Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene. 2003; 22(39): 7989–7997.
  34. Park J, Park K, Kim S, et al. Msx1 Gene Overexpression Induces G1 Phase Cell Arrest in Human Ovarian Cancer Cell Line OVCAR3. Biochemical and Biophysical Research Communications. 2001; 281(5): 1234–1240.

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