Vol 89, No 12 (2018)
Review paper
Published online: 2018-12-28
Current treatment options for advanced choriocarcinoma on the basis of own case and review of the literature
Abstract
Choriocarcinoma is one of rare neoplasms of female reproductive organs. In the last decade only a few cases of this disease have been registered in Poland. The paper presents the current principles of diagnosis and treatment options for this rare disease based on the authors’ clinical experience (description of the case) and literature review. This paper provides basic information on epidemiology, FIGO classification, and also discusses the chemotherapy regimens used in the medical treatment of choriocarcinoma. Surgical options were also considered.
A thematic review of the most important papers published in international journals in recent years has also been made.
Keywords: choriocarcinomatrophoblast tumourgestational trophoblastic disease
References
- Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010; 203(6): 531–539.
- Goldstein DP, Berkowitz RS. Current management of gestational trophoblastic neoplasia. Hematol Oncol Clin North Am. 2012; 26(1): 111–131.
- Tarney CM, Tian C, Craig ER, et al. Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma. Int J Gynecol Cancer. 2018; 28(2): 338–345.
- Soper JT. Gestational trophoblastic disease. Obstet Gynecol. 2006; 108(1): 176–187.
- Seckl M, Sebire N, Berkowitz R. Gestational trophoblastic disease. The Lancet. 2010; 376(9742): 717–729.
- Lin LH, Fushida K, Hase EA, et al. Gestational Tubal Choriocarcinoma Presenting as a Pregnancy of Unknown Location following Ovarian Induction. Case Rep Obstet Gynecol. 2018; 2018: 4705192.
- Han V, Kaye S. A Rare Case of Gestational Choriocarcinoma Presenting as Cornual Ectopic Pregnancy. J Obstet Gynaecol Can. 2018; 40(3): 351–353.
- Liu S, Fan C, Feng F, et al. Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. Cancer Biol Med. 2017; 14(2): 191–193.
- Ngan H, Bender H, Benedet JL, et al. Gestational trophoblastic neoplasia, FIGO 2000 staging and classification. International Journal of Gynecology & Obstetrics. 2004; 83: 175–177.
- Wojciechowska U, Didkowska J. Zachorowania i zgony na nowotwory złośliwe w Polsce. KRN, Centrum Onkologii, Instytut Marie Skłodowskiej-Curie, www.onkologia.org.pl. 2014.
- FIGO Oncology Committee. FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Oncology Committee. Int J Gynaecol Obstet. 2002; 77(3): 285–287.
- Suzuka K. Adjuvant hysterectomy in low-risk gestational trophoblastic disease. Obstetrics & Gynecology. 2001; 97(3): 431–434.
- Mangili G, Lorusso D, Brown J, et al. Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer. 2014; 24(9 Suppl 3): S109–S116.
- Soper JT. Role of surgery and radiation therapy in the management of gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol. 2003; 17(6): 943–957.
- Gavanier D, Leport H, Massardier J, et al. Gestational trophoblastic neoplasia with brain metastasis at initial presentation: a retrospective study. Int J Clin Oncol. 2018 [Epub ahead of print].
- Frost AS, Sherman JH, Rezaei K, et al. Choriocarcinoma with brain, lung and vaginal metastases successfully treated without brain radiation or intrathecal chemotherapy: A case report. Gynecol Oncol Rep. 2017; 20: 97–99.
- Hanna RK, Soper JT. The role of surgery and radiation therapy in the management of gestational trophoblastic disease. Oncologist. 2010; 15(6): 593–600.
- Vaid N, Kaur C, Vidya S, et al. A Case Report on Radiotherapy in Choriocarcinoma: A Life Saving Procedure. Asia-Oceania Journal of Obstetrics and Gynaecology. 2010; 20(3): 245–247.
- Gestational Trophoblastic Disease. 2012.
- Lawrie T, Alazzam M, Tidy J, et al. First-line chemotherapy in low-risk gestational trophoblastic neoplasia. Cochrane Database of Systematic Reviews. 2016.
- Deng L, Zhang J, Wu T, et al. Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour. Cochrane Database of Systematic Reviews. 2013.
- Dhanushkodi M, Ganesan T, Sagar TG. Refractory Choriocarcinoma: Complete Response With Oral Etoposide. J Glob Oncol. 2017; 3(5): 678–679.
- Wang Q, Fu J, Hu L, et al. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database of Systematic Reviews. 2017.
- Braga A, Campos V, Filho JR, et al. Is chemotherapy always necessary for patients with nonmetastatic gestational trophoblastic neoplasia with histopathological diagnosis of choriocarcinoma? Gynecol Oncol. 2018; 148(2): 239–246.
