open access

Vol 89, No 8 (2018)
Research paper
Published online: 2018-08-31
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The role of osteopontin in the pathogenesis of placenta percreta

Alev Özer1, Aslı Yaylalı, Sezen Koçarslan
DOI: 10.5603/GP.a2018.0075
·
Pubmed: 30215463
·
Ginekol Pol 2018;89(8):438-442.
Affiliations
  1. Kahramanmaras Sutcu Imam University, 46000 Kahramanmaras, Turkey

open access

Vol 89, No 8 (2018)
ORIGINAL PAPERS Obstetrics
Published online: 2018-08-31

Abstract

Objective: This study aims to determine how the expression of osteopontin is altered in the placenta percreta by compar­ing osteopontin expression in normal placentas and placenta percreta tissues.

Material and methods: Placental tissues from hysterectomy materials which were histopathologically diagnosed with placenta percreta (study group, n = 20) and placental tissues obtained from normal term pregnancies (control group, n = 20) were immunohistochemically stained with osteopontin antibody. The groups were compared with respect to the intensity of cytoplasmic staining for osteopontin.

Results: The study and control groups were similar with respect to age, gravidity, parity, gestational age at birth, number of previous cesarean deliveries and curettages and (p > 0.05 for all). Immediate postoperative hemoglobin was significantly lower and the need for blood transfusion was significantly higher in the study group (p = 0.001 for both). Placental osteo­pontin expression was significantly altered in the study group (p = 0.020). Negative staining for placental osteopontin was significantly more frequent in the placenta percreta group than the control group (9/20 vs 0/20, 45.0% vs 0%, p = 0.037).

Conclusion: As reduced placental osteopontin expression was determined in the placenta percreta cases compared to the normal term placenta tissues, osteopontin can be considered to have a role in morbidly adherent placentation. This study is of value as the first study to investigate the changes in osteopontin expression in placenta percreta cases.

Abstract

Objective: This study aims to determine how the expression of osteopontin is altered in the placenta percreta by compar­ing osteopontin expression in normal placentas and placenta percreta tissues.

Material and methods: Placental tissues from hysterectomy materials which were histopathologically diagnosed with placenta percreta (study group, n = 20) and placental tissues obtained from normal term pregnancies (control group, n = 20) were immunohistochemically stained with osteopontin antibody. The groups were compared with respect to the intensity of cytoplasmic staining for osteopontin.

Results: The study and control groups were similar with respect to age, gravidity, parity, gestational age at birth, number of previous cesarean deliveries and curettages and (p > 0.05 for all). Immediate postoperative hemoglobin was significantly lower and the need for blood transfusion was significantly higher in the study group (p = 0.001 for both). Placental osteo­pontin expression was significantly altered in the study group (p = 0.020). Negative staining for placental osteopontin was significantly more frequent in the placenta percreta group than the control group (9/20 vs 0/20, 45.0% vs 0%, p = 0.037).

Conclusion: As reduced placental osteopontin expression was determined in the placenta percreta cases compared to the normal term placenta tissues, osteopontin can be considered to have a role in morbidly adherent placentation. This study is of value as the first study to investigate the changes in osteopontin expression in placenta percreta cases.

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Keywords

immunohistochemistry; osteopontin; placenta percrata

About this article
Title

The role of osteopontin in the pathogenesis of placenta percreta

Journal

Ginekologia Polska

Issue

Vol 89, No 8 (2018)

Article type

Research paper

Pages

438-442

Published online

2018-08-31

DOI

10.5603/GP.a2018.0075

Pubmed

30215463

Bibliographic record

Ginekol Pol 2018;89(8):438-442.

Keywords

immunohistochemistry
osteopontin
placenta percrata

Authors

Alev Özer
Aslı Yaylalı
Sezen Koçarslan

References (20)
  1. Baird SM, Troiano NH, Kennedy MB. Morbidly Adherent Placenta: Interprofessional Management Strategies for the Intrapartum Period. J Perinat Neonatal Nurs. 2016; 30(4): 319–326.
  2. Martinez W. Abnormal adherence of the placenta: placenta accreta, increta, percreta. MD Advis. 2015; 8(4): 32–34.
  3. Parra-Herran C, Djordjevic B. Histopathology of placenta creta: chorionic villi intrusion into myometrial vascular spaces and extravillous trophoblast proliferation are frequent and specific findings with implications for diagnosis and pathogenesis. Int J Gynecol Pathol. 2016; 35(6): 497–508.
  4. Hannon T, Innes BA, Lash GE, et al. Effects of local decidua on trophoblast invasion and spiral artery remodeling in focal placenta creta - an immunohistochemical study. Placenta. 2012; 33(12): 998–1004.
  5. Tantbirojn P, Crum CP, Parast MM. Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast. Placenta. 2008; 29(7): 639–645.
  6. Ramchandani D, Weber GF. Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer. Biochim Biophys Acta. 2015; 1855(2): 202–222.
  7. Bandopadhyay M, Bulbule A, Butti R, et al. Osteopontin as a therapeutic target for cancer. Expert Opin Ther Targets. 2014; 18(8): 883–895.
  8. Shevde LA, Samant RS. Role of osteopontin in the pathophysiology of cancer. Matrix Biol. 2014; 37: 131–141.
  9. Silva JF, Serakides R. Intrauterine trophoblast migration: A comparative view of humans and rodents. Cell Adh Migr. 2016; 10(1-2): 88–110.
  10. Johnson GA, Burghardt RC, Bazer FW, et al. Analysis of osteopontin at the maternal-placental interface in pigs. Biol Reprod. 2002; 66(3): 718–725.
  11. Burghardt RC, Johnson GA, Jaeger LA, et al. Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals. Cells Tissues Organs. 2002; 172(3): 202–217.
  12. Štemberger C, Matušan-Ilijaš K, Avirović M, et al. Osteopontin is associated with decreased apoptosis and αv integrin expression in lung adenocarcinoma. Acta Histochem. 2014; 116(1): 222–229.
  13. Kocarslan S, Incebıyık A, Guldur ME, et al. What is the role of matrix metalloproteinase-2 in placenta percreta? J Obstet Gynaecol Res. 2015; 41(7): 1018–1022.
  14. Sharma S, Godbole G, Modi D. Decidual Control of Trophoblast Invasion. Am J Reprod Immunol. 2016; 75(3): 341–350.
  15. Wortman AC, Alexander JM. Placenta accreta, increta, and percreta. Obstet Gynecol Clin North Am. 2013; 40(1): 137–154.
  16. Zhou H, Xu WM, Qi QR. et a. Osteopontin reguates trophobast proiferation and invasion and associates with spontaneous abortion during eary pregnancy. Int J Cin Exp Patho. l. 2016; 9: 5230–5239.
  17. Li MC, Fang Q, He ZM, et al. Placental expression of osteopontin(OPN) in monochorionic twins with discordant growth. Placenta. 2013; 34(3): 288–290.
  18. Xia J, Qiao F, Su F, et al. Implication of expression of osteopontin and its receptor integrin alphanubeta3 in the placenta in the development of preeclampsia. J Huazhong Univ Sci Technolog Med Sci. 2009; 29(6): 755–760.
  19. Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev. 2009; 28(1-2): 151–166.
  20. Batorfi J, Fulop V, Kim JH, et al. Osteopontin is down-regulated in hydatidiform mole. Gynecol Oncol. 2003; 89(1): 134–139.

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