open access

Vol 88, No 8 (2017)
Research paper
Published online: 2017-08-31
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Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Jakub Kornacki1, Magdalena Adamczyk, Przemysław Wirstlein, Maciej Osiński, Ewa Wender-Ożegowska
DOI: 10.5603/GP.a2017.0081
·
Pubmed: 28930371
·
Ginekol Pol 2017;88(8):442-445.
Affiliations
  1. Division of Reproduction, Department of Obstetrics, Gynaecology and Gynaecologic Oncology, Poznan University of Medical Sciences, Poland

open access

Vol 88, No 8 (2017)
ORIGINAL PAPERS Obstetrics
Published online: 2017-08-31

Abstract

Objectives: The aims of our study were to assess the correlation between the amniotic fluid index (AFI) value and the frequency and type of fetal anomalies.

Material and methods: The material included 94 patients at the third trimester of pregnancy, 60 with mild polyhydramnios, 19 with moderate one, and 15 with severe one. Polyhydramnios was diagnosed if AFI was > 24 cm. All patients were divided into three groups based on the value of AFI: 1) mild polyhydramnios with AFI between 24.1 and 29.9 cm, 2) moderate polyhydramnios with AFI between 30–34.9 cm, and 3) severe polyhydramnios with AFI ≥ 35 cm.

Results: The incidence of fetal malformations correlated significantly with the degree of polyhydramnios and was the highest in patients with severe polyhydramnios (53.3%, p = 0.002). Congenital malformations of the gastrointestinal tract were the most frequent fetal anomalies in the whole group of patients (5.3%). Trisomy 18 was the most frequent aneuploidy found in women with polyhydramnios (2.1%).

Conclusions:

  1. The incidence of fetal congenital anomalies significantly increases with the degree of polyhydramnios, being most frequent in severe one and rather rare in a mild one.
  2. Congenital malformations of the gastrointestinal tract were the most frequent anomalies in patients with polyhy­dramnios, especially in women with severe polyhydramnios.

Abstract

Objectives: The aims of our study were to assess the correlation between the amniotic fluid index (AFI) value and the frequency and type of fetal anomalies.

Material and methods: The material included 94 patients at the third trimester of pregnancy, 60 with mild polyhydramnios, 19 with moderate one, and 15 with severe one. Polyhydramnios was diagnosed if AFI was > 24 cm. All patients were divided into three groups based on the value of AFI: 1) mild polyhydramnios with AFI between 24.1 and 29.9 cm, 2) moderate polyhydramnios with AFI between 30–34.9 cm, and 3) severe polyhydramnios with AFI ≥ 35 cm.

Results: The incidence of fetal malformations correlated significantly with the degree of polyhydramnios and was the highest in patients with severe polyhydramnios (53.3%, p = 0.002). Congenital malformations of the gastrointestinal tract were the most frequent fetal anomalies in the whole group of patients (5.3%). Trisomy 18 was the most frequent aneuploidy found in women with polyhydramnios (2.1%).

Conclusions:

  1. The incidence of fetal congenital anomalies significantly increases with the degree of polyhydramnios, being most frequent in severe one and rather rare in a mild one.
  2. Congenital malformations of the gastrointestinal tract were the most frequent anomalies in patients with polyhy­dramnios, especially in women with severe polyhydramnios.
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Keywords

fetal ultrasound, fetal malformations, gastrointestinal tract, central nervous system

About this article
Title

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Journal

Ginekologia Polska

Issue

Vol 88, No 8 (2017)

Article type

Research paper

Pages

442-445

Published online

2017-08-31

DOI

10.5603/GP.a2017.0081

Pubmed

28930371

Bibliographic record

Ginekol Pol 2017;88(8):442-445.

Keywords

fetal ultrasound
fetal malformations
gastrointestinal tract
central nervous system

Authors

Jakub Kornacki
Magdalena Adamczyk
Przemysław Wirstlein
Maciej Osiński
Ewa Wender-Ożegowska

References (13)
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  2. Sagi-Dain L, Sagi S. Chromosomal aberrations in idiopathic polyhydramnios: A systematic review and meta-analysis. Eur J Med Genet. 2015; 58(8): 409–415.
  3. Yeung Leung T, Hung Suen SS. Manipaulation of amniotic fluid volume:oligohydramnios and polyhydramnios. In: Kliby MD, Oepkes D, Johnson A. ed. Fetal therapy Scientific Basis and Critical Appraisal of Clinical Benefits. Cambridge Raven Press, New York 2013: 137–144.
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  8. Magann EF, Chauhan SP, Doherty DA, et al. A review of idiopathic hydramnios and pregnancy outcomes. Obstet Gynecol Surv. 2007; 62(12): 795–802.
  9. Harman CR. Amniotic fluid abnormalities. Semin Perinatol. 2008; 32(4): 288–294.
  10. Dashe JS, McIntire DD, Ramus RM, et al. Hydramnios: anomaly prevalence and sonographic detection. Obstet Gynecol. 2002; 100(1): 134–139.
  11. Kleine RT, Bernardes LS, Carvalho MA, et al. Pregnancy outcomes in severe polyhydramnios: no increase in risk in patients needing amnioreduction for maternal pain or respiratory distress. J Matern Fetal Neonatal Med. 2016; 29(24): 4031–4034.
  12. Boito S, Crovetto F, Ischia B, et al. Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios. Prenat Diagn. 2016; 36(8): 726–730.
  13. Yefet E, Daniel-Spiegel E. Outcomes From Polyhydramnios With Normal Ultrasound. Pediatrics. 2016; 137(2): e20151948.

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