open access

Vol 88, No 3 (2017)
Research paper
Published online: 2017-03-31
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Does the patients age at cancer diagnosis affect microvessels density in uterine sarcoma tissues?

Marcin Bobiński, Wiesława Bednarek, Karolina Okła, Grzegorz Polak, Małgorzata Sobstyl, Iwona Wertel, Jan Kotarski
DOI: 10.5603/GP.a2017.0026
·
Pubmed: 28397202
·
Ginekol Pol 2017;88(3):138-140.

open access

Vol 88, No 3 (2017)
ORIGINAL PAPERS Gynecology
Published online: 2017-03-31

Abstract

Objectives: The objective of the study was to retrospectively evaluate the density of vessels exhibiting positive glycoprotein CD34 expression in the uterine leiomyosarcoma tissues and their correlation with the age of patients at the time of tumor diagnosis.

Material and methods: The archival paraffin blocks with the cancer tissues collected from 50 patients suffering from uterine leiomyosarcoma were used together with their clinical and demographic data. The immunohistochemical peroxidase-de­pendent methods were used to detect microvessels with positive CD34 expression. The glycoprotein CD34 expression was evaluated as a density of microvessel showing the positive immunohistochemical reaction (MVDCD34).

Results: The negative, statistically significant correlation between the age of patients (at the moment diagnosis) and the MVDCD34+ (R = –0.289, p = 0.042) was found.

Conclusions: The study’s findings may suggest that the tissues of younger people constitute a permissive environment for pro-angiogenic factors.

Abstract

Objectives: The objective of the study was to retrospectively evaluate the density of vessels exhibiting positive glycoprotein CD34 expression in the uterine leiomyosarcoma tissues and their correlation with the age of patients at the time of tumor diagnosis.

Material and methods: The archival paraffin blocks with the cancer tissues collected from 50 patients suffering from uterine leiomyosarcoma were used together with their clinical and demographic data. The immunohistochemical peroxidase-de­pendent methods were used to detect microvessels with positive CD34 expression. The glycoprotein CD34 expression was evaluated as a density of microvessel showing the positive immunohistochemical reaction (MVDCD34).

Results: The negative, statistically significant correlation between the age of patients (at the moment diagnosis) and the MVDCD34+ (R = –0.289, p = 0.042) was found.

Conclusions: The study’s findings may suggest that the tissues of younger people constitute a permissive environment for pro-angiogenic factors.

Get Citation

Keywords

microvessels density, uterine sarcoma, patient age

About this article
Title

Does the patients age at cancer diagnosis affect microvessels density in uterine sarcoma tissues?

Journal

Ginekologia Polska

Issue

Vol 88, No 3 (2017)

Article type

Research paper

Pages

138-140

Published online

2017-03-31

DOI

10.5603/GP.a2017.0026

Pubmed

28397202

Bibliographic record

Ginekol Pol 2017;88(3):138-140.

Keywords

microvessels density
uterine sarcoma
patient age

Authors

Marcin Bobiński
Wiesława Bednarek
Karolina Okła
Grzegorz Polak
Małgorzata Sobstyl
Iwona Wertel
Jan Kotarski

References (12)
  1. Wang Y, Yao X, Ge J, et al. Can vascular endothelial growth factor and microvessel density be used as prognostic biomarkers for colorectal cancer? A systematic review and meta-analysis. ScientificWorldJournal. 2014: 102736.
  2. Sacewicz I, Wiktorska M, Wysocki T, et al. Mechanisms of cancer angiogenesis Postepy Hig Med Dosw. 2009; 14(63): 159–168.
  3. Szala S, Jarosz M. Nowotworowe naczynia krwionośne. Postępy Higieny i Medycyny Doświadczalnej. 2011; 65: 437–446.
  4. Holyoake TL, Alcorn MJ, Franklin IM. The CD34 antigen: potential clinical advantages of CD34 selection. Clin Oncol (R Coll Radiol). 1996; 8(4): 214–221.
  5. Czekierdowski A, Czekierdowska S, Daniłoś J. Ocena roli badania zjawiska „mimikry naczyniowej” i gęstości mikronaczyń w nowotworach złośliwych jajnika u kobiet. Prz Menopauz. 2011; 2: 95–101.
  6. Dharmalingam P, Roopesh Kumar VR, Verma SK. Vascular endothelial growth factor expression and angiogenesis in various grades and subtypes of meningioma. Indian J Pathol Microbiol. 2013; 56(4): 349–354.
  7. Reed MJ, Karres N, Eyman D, et al. The effects of aging on tumor growth and angiogenesis are tumor-cell dependent. Int J Cancer. 2007; 120(4): 753–760.
  8. Sadoun E, Reed MJ. Impaired angiogenesis in aging is associated with alterations in vessel density, matrix composition, inflammatory response, and growth factor expression. J Histochem Cytochem. 2003; 51(9): 1119–1130.
  9. Kubo T, Shimose S, Fujimori J, et al. Diversity of angiogenesis among malignant bone tumors. Mol Clin Oncol. 2013; 1(1): 131–136.
  10. Anders CK, Hsu DS, Broadwater G, et al. Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol. 2008; 26(20): 3324–3330.
  11. Colak D, Nofal A, Albakheet A, et al. Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women. PLoS One. 2013; 8(5): e63204.
  12. Ito Y, Miyauchi A, Kihara M, et al. Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation. Thyroid. 2014; 24(1): 27–34.

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