open access

Vol 87, No 8 (2016)
Research paper
Published online: 2016-08-31
Get Citation

Alternative tumor markers in the diagnosis of ovarian cancer

Burcu Kısa Karakaya, Eralp Başer, Berk Bildacı, Esra Çabuk Cömert, Nilufer Bayraktar, Polat Dursun, Esra Kuşçu, Ali Ayhan
DOI: 10.5603/GP.2016.0045
·
Pubmed: 27629130
·
Ginekol Pol 2016;87(8):565-769.

open access

Vol 87, No 8 (2016)
ORIGINAL PAPERS Gynecology
Published online: 2016-08-31

Abstract

Objectives: The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses.

Material and methods: Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, Ankara, Turkey, between November 2010 and March 2011. Fifty patients with a suspicion of malignant adnexal mass and 30 controls were included in the study. Serum and urine CA-125, HE4, and bcl2 levels were evaluated for their role in the diagnosis of epithelial ovarian cancer (EOC).

Results: Serum CA-125 and HE4 levels, and urine HE4 levels were significantly higher in malignant cases as compared to controls (p < 0.05). Mean levels of bcl2 in saliva and urine were similar in malignant cases and controls (p > 0.05).

Conclusions: We demonstrated that serum CA125, serum HE4 and urine HE4 levels were elevated in patients with ovarian cancer. These findings should be assessed in future studies with larger sample sizes in order to reach more definite conclusions.

Abstract

Objectives: The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses.

Material and methods: Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, Ankara, Turkey, between November 2010 and March 2011. Fifty patients with a suspicion of malignant adnexal mass and 30 controls were included in the study. Serum and urine CA-125, HE4, and bcl2 levels were evaluated for their role in the diagnosis of epithelial ovarian cancer (EOC).

Results: Serum CA-125 and HE4 levels, and urine HE4 levels were significantly higher in malignant cases as compared to controls (p < 0.05). Mean levels of bcl2 in saliva and urine were similar in malignant cases and controls (p > 0.05).

Conclusions: We demonstrated that serum CA125, serum HE4 and urine HE4 levels were elevated in patients with ovarian cancer. These findings should be assessed in future studies with larger sample sizes in order to reach more definite conclusions.

Get Citation

Keywords

adnexal mass, ovarian cancer, tumor marker, CA125, HE4, bcl2

About this article
Title

Alternative tumor markers in the diagnosis of ovarian cancer

Journal

Ginekologia Polska

Issue

Vol 87, No 8 (2016)

Article type

Research paper

Pages

565-769

Published online

2016-08-31

DOI

10.5603/GP.2016.0045

Pubmed

27629130

Bibliographic record

Ginekol Pol 2016;87(8):565-769.

Keywords

adnexal mass
ovarian cancer
tumor marker
CA125
HE4
bcl2

Authors

Burcu Kısa Karakaya
Eralp Başer
Berk Bildacı
Esra Çabuk Cömert
Nilufer Bayraktar
Polat Dursun
Esra Kuşçu
Ali Ayhan

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl