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Alternative tumor markers in the diagnosis of ovarian cancer
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Abstract
Objectives: The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses.
Material and methods: Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, Ankara, Turkey, between November 2010 and March 2011. Fifty patients with a suspicion of malignant adnexal mass and 30 controls were included in the study. Serum and urine CA-125, HE4, and bcl2 levels were evaluated for their role in the diagnosis of epithelial ovarian cancer (EOC).
Results: Serum CA-125 and HE4 levels, and urine HE4 levels were significantly higher in malignant cases as compared to controls (p < 0.05). Mean levels of bcl2 in saliva and urine were similar in malignant cases and controls (p > 0.05).
Conclusions: We demonstrated that serum CA125, serum HE4 and urine HE4 levels were elevated in patients with ovarian cancer. These findings should be assessed in future studies with larger sample sizes in order to reach more definite conclusions.
Abstract
Objectives: The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses.
Material and methods: Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, Ankara, Turkey, between November 2010 and March 2011. Fifty patients with a suspicion of malignant adnexal mass and 30 controls were included in the study. Serum and urine CA-125, HE4, and bcl2 levels were evaluated for their role in the diagnosis of epithelial ovarian cancer (EOC).
Results: Serum CA-125 and HE4 levels, and urine HE4 levels were significantly higher in malignant cases as compared to controls (p < 0.05). Mean levels of bcl2 in saliva and urine were similar in malignant cases and controls (p > 0.05).
Conclusions: We demonstrated that serum CA125, serum HE4 and urine HE4 levels were elevated in patients with ovarian cancer. These findings should be assessed in future studies with larger sample sizes in order to reach more definite conclusions.
Keywords
adnexal mass, ovarian cancer, tumor marker, CA125, HE4, bcl2
About this articleTitle
Alternative tumor markers in the diagnosis of ovarian cancer
Journal
Issue
Article type
Research paper
Pages
565-769
Published online
2016-08-31
Page views
2246
Article views/downloads
2350
DOI
Pubmed
Bibliographic record
Ginekol Pol 2016;87(8):565-769.
Keywords
adnexal mass
ovarian cancer
tumor marker
CA125
HE4
bcl2
Authors
Burcu Kısa Karakaya
Eralp Başer
Berk Bildacı
Esra Çabuk Cömert
Nilufer Bayraktar
Polat Dursun
Esra Kuşçu
Ali Ayhan
