open access

Vol 88, No 3 (2017)
Research paper
Published online: 2017-03-31
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Comparison of the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low-grade and high-grade squamous intraepithelial lesions across different age groups

Aleksandra Paluszkiewicz, Dominik Pruski, Kinga Iwaniec, Witold Kędzia
DOI: 10.5603/GP.a2017.0027
·
Pubmed: 28397203
·
Ginekol Pol 2017;88(3):141-146.

open access

Vol 88, No 3 (2017)
ORIGINAL PAPERS Gynecology
Published online: 2017-03-31

Abstract

Objectives: To assess the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low grade and high-grade squamous intraepithelial lesions across different age groups.

Material and methods: The study included 1103 patients, age 25–70 years. All patients underwent in-depth diagnostic tests following either an abnormal Pap test result or a clinically suspicious cervical lesion. In all women the following examinations were performed: a molecular test detecting 14 high-risk types of HPV, a colposcopy examination, as well as directed-biopsy of the cervix. The studied population was subdivided into four age groups.

Results: It was observed that the percentage of high grade squamous intraepithelial lesions (HSIL) and cancers increased with women’s age. Sensitivity of both methods for detecting high-grade squamous intraepithelial lesions was highest for women aged 40–49 years. Sensitivity values of HPV testing was higher than that of cervical cytology among women under age 50.

Conclusions: Specificity of HPV testing increased significantly with age of women and was several fold higher across all age groups than the specificity of cervical cytology.

Abstract

Objectives: To assess the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low grade and high-grade squamous intraepithelial lesions across different age groups.

Material and methods: The study included 1103 patients, age 25–70 years. All patients underwent in-depth diagnostic tests following either an abnormal Pap test result or a clinically suspicious cervical lesion. In all women the following examinations were performed: a molecular test detecting 14 high-risk types of HPV, a colposcopy examination, as well as directed-biopsy of the cervix. The studied population was subdivided into four age groups.

Results: It was observed that the percentage of high grade squamous intraepithelial lesions (HSIL) and cancers increased with women’s age. Sensitivity of both methods for detecting high-grade squamous intraepithelial lesions was highest for women aged 40–49 years. Sensitivity values of HPV testing was higher than that of cervical cytology among women under age 50.

Conclusions: Specificity of HPV testing increased significantly with age of women and was several fold higher across all age groups than the specificity of cervical cytology.

Get Citation

Keywords

Pap test, HPV testing, low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), age groups

About this article
Title

Comparison of the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low-grade and high-grade squamous intraepithelial lesions across different age groups

Journal

Ginekologia Polska

Issue

Vol 88, No 3 (2017)

Article type

Research paper

Pages

141-146

Published online

2017-03-31

DOI

10.5603/GP.a2017.0027

Pubmed

28397203

Bibliographic record

Ginekol Pol 2017;88(3):141-146.

Keywords

Pap test
HPV testing
low-grade squamous intraepithelial lesions (LSIL)
high-grade squamous intraepithelial lesions (HSIL)
age groups

Authors

Aleksandra Paluszkiewicz
Dominik Pruski
Kinga Iwaniec
Witold Kędzia

References (13)
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