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Chronic and gestational metabolic disorders have a different impact on late-pregnancy endothelial function in pregnant women
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Abstract
Objectives: We investigated how maternal endothelial function is affected by pregestational (Type 1) diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) and/or chronic hypertension (chHT) or gestational hypertension (PIH).
Methods: We conducted a prospective, observational study involving 78 participants with GDM, PGDM and/or hypertension (PIH-16, GDM + PIH-14, PGDM + chHT-8, PGDM-20, GDM-20) in the third trimester of a singleton viable pregnancy. Twenty healthy women with uncomplicated pregnancies matched for gestational age served as controls. We analysed maternal data, disease history and serum concentrations of E-selectin and Vascular cell
adhesion molecule 1 (sVCAM-1).
Results: Only the maternal serum concentration of sVCAM-1 differed significantly among the subgroups (p< 0.0001), with the highest levels evident in women with PIH or GDM + PIH and the lowest in women with PGDM alone or PGDM + chHT.
Conclusions: Pregestational or pregnancy associated disorders, although sharing similar clinical symptoms, have a different impact on endothelial function in pregnant women.
Abstract
Objectives: We investigated how maternal endothelial function is affected by pregestational (Type 1) diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) and/or chronic hypertension (chHT) or gestational hypertension (PIH).
Methods: We conducted a prospective, observational study involving 78 participants with GDM, PGDM and/or hypertension (PIH-16, GDM + PIH-14, PGDM + chHT-8, PGDM-20, GDM-20) in the third trimester of a singleton viable pregnancy. Twenty healthy women with uncomplicated pregnancies matched for gestational age served as controls. We analysed maternal data, disease history and serum concentrations of E-selectin and Vascular cell
adhesion molecule 1 (sVCAM-1).
Results: Only the maternal serum concentration of sVCAM-1 differed significantly among the subgroups (p< 0.0001), with the highest levels evident in women with PIH or GDM + PIH and the lowest in women with PGDM alone or PGDM + chHT.
Conclusions: Pregestational or pregnancy associated disorders, although sharing similar clinical symptoms, have a different impact on endothelial function in pregnant women.
Keywords
cell adhesion molecules; pregnancy; type 1 diabetes; hypertension; vascular endothelium
About this articleTitle
Chronic and gestational metabolic disorders have a different impact on late-pregnancy endothelial function in pregnant women
Journal
Issue
Article type
Research paper
Pages
283-287
Published online
2016-05-23
Page views
903
Article views/downloads
931
DOI
10.17772/gp/62209
Pubmed
Bibliographic record
Ginekol Pol 2016;87(4):283-287.
Keywords
cell adhesion molecules
pregnancy
type 1 diabetes
hypertension
vascular endothelium
Authors
Agnieszka Zawiejska
Ewa Wender-Ożegowska
Jacek Brazert
