open access

Vol 87, No 4 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-05-23
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Chronic and gestational metabolic disorders have a different impact on late-pregnancy endothelial function in pregnant women

Agnieszka Zawiejska, Ewa Wender-Ożegowska, Jacek Brazert
DOI: 10.17772/gp/62209
·
Pubmed: 27321100
·
Ginekol Pol 2016;87(4):283-287.

open access

Vol 87, No 4 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-05-23

Abstract

Objectives: We investigated how maternal endothelial function is affected by pregestational (Type 1) diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) and/or chronic hypertension (chHT) or gestational hypertension (PIH).

Methods: We conducted a prospective, observational study involving 78 participants with GDM, PGDM and/or hypertension (PIH-16, GDM + PIH-14, PGDM + chHT-8, PGDM-20, GDM-20) in the third trimester of a singleton viable pregnancy. Twenty healthy women with uncomplicated pregnancies matched for gestational age served as controls. We analysed maternal data, disease history and serum concentrations of E-selectin and Vascular cell

adhesion molecule 1 (sVCAM-1).

Results: Only the maternal serum concentration of sVCAM-1 differed significantly among the subgroups (p< 0.0001), with the highest levels evident in women with PIH or GDM + PIH and the lowest in women with PGDM alone or PGDM + chHT.

Conclusions: Pregestational or pregnancy associated disorders, although sharing similar clinical symptoms, have a different impact on endothelial function in pregnant women.

Abstract

Objectives: We investigated how maternal endothelial function is affected by pregestational (Type 1) diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) and/or chronic hypertension (chHT) or gestational hypertension (PIH).

Methods: We conducted a prospective, observational study involving 78 participants with GDM, PGDM and/or hypertension (PIH-16, GDM + PIH-14, PGDM + chHT-8, PGDM-20, GDM-20) in the third trimester of a singleton viable pregnancy. Twenty healthy women with uncomplicated pregnancies matched for gestational age served as controls. We analysed maternal data, disease history and serum concentrations of E-selectin and Vascular cell

adhesion molecule 1 (sVCAM-1).

Results: Only the maternal serum concentration of sVCAM-1 differed significantly among the subgroups (p< 0.0001), with the highest levels evident in women with PIH or GDM + PIH and the lowest in women with PGDM alone or PGDM + chHT.

Conclusions: Pregestational or pregnancy associated disorders, although sharing similar clinical symptoms, have a different impact on endothelial function in pregnant women.

Get Citation

Keywords

cell adhesion molecules; pregnancy; type 1 diabetes; hypertension; vascular endothelium

About this article
Title

Chronic and gestational metabolic disorders have a different impact on late-pregnancy endothelial function in pregnant women

Journal

Ginekologia Polska

Issue

Vol 87, No 4 (2016)

Pages

283-287

Published online

2016-05-23

DOI

10.17772/gp/62209

Pubmed

27321100

Bibliographic record

Ginekol Pol 2016;87(4):283-287.

Keywords

cell adhesion molecules
pregnancy
type 1 diabetes
hypertension
vascular endothelium

Authors

Agnieszka Zawiejska
Ewa Wender-Ożegowska
Jacek Brazert

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