open access

Vol 87, No 4 (2016)
REVIEW PAPERS Gynecology
Published online: 2016-05-23
Get Citation

Chemotherapy-induced peripheral neuropathy — epidemiology and pathogenesis

Dariusz Iżycki, Adam Niezgoda, Maciej Kaźmierczak, Ewa Nowak-Markwitz
DOI: 10.17772/gp/61750
·
Pubmed: 27321102
·
Ginekol Pol 2016;87(4):293-299.

open access

Vol 87, No 4 (2016)
REVIEW PAPERS Gynecology
Published online: 2016-05-23

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most important neurologic complications experienced by patients receiving chemotherapy. The neuropathy often interferes with daily activities and exercise leading to severe impairment of the patient’s quality of life (QoL). The evolution of most CIPNs is characterized by a gradual onset of signs/symptoms, beginning in the lower limbs and advancing proximally into a bilateral stocking and glove distribution. Patients often complain of numbness, tingling and pain in the affected areas. The symptoms become aggravated with repeated cycles of chemotherapy. When the offending agent is withheld, the symptoms generally abate, but relief is not guaranteed. The consequences of delay or discontinuation of treatment may affect overall patient survival.

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most important neurologic complications experienced by patients receiving chemotherapy. The neuropathy often interferes with daily activities and exercise leading to severe impairment of the patient’s quality of life (QoL). The evolution of most CIPNs is characterized by a gradual onset of signs/symptoms, beginning in the lower limbs and advancing proximally into a bilateral stocking and glove distribution. Patients often complain of numbness, tingling and pain in the affected areas. The symptoms become aggravated with repeated cycles of chemotherapy. When the offending agent is withheld, the symptoms generally abate, but relief is not guaranteed. The consequences of delay or discontinuation of treatment may affect overall patient survival.

Get Citation

Keywords

cancer; pathogenesis; chemotherapy; epidemiology; peripheral neuropathy

About this article
Title

Chemotherapy-induced peripheral neuropathy — epidemiology and pathogenesis

Journal

Ginekologia Polska

Issue

Vol 87, No 4 (2016)

Pages

293-299

Published online

2016-05-23

DOI

10.17772/gp/61750

Pubmed

27321102

Bibliographic record

Ginekol Pol 2016;87(4):293-299.

Keywords

cancer
pathogenesis
chemotherapy
epidemiology
peripheral neuropathy

Authors

Dariusz Iżycki
Adam Niezgoda
Maciej Kaźmierczak
Ewa Nowak-Markwitz

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