open access

Vol 87, No 4 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-05-23
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Increased serum ghrelin in preeclampsia: is ghrelin a friend or a foe?

Onur Erol, Hamit Y. Ellidağ, Hülya Ayık, Gül A. Bülbül, Aysel U. Derbent, Sibel Kulaksızoğlu, Necat Yılmaz
DOI: 10.17772/gp/57852
·
Pubmed: 27321099
·
Ginekol Pol 2016;87(4):277-282.

open access

Vol 87, No 4 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-05-23

Abstract

Objectives: To investigate maternal serum ghrelin levels in pregnancies complicated by preeclampsia and to explore the relationship between ghrelin level and disease severity.

Materials and methods: This case-control study included 40 healthy pregnant women, 42 women with mild preeclampsia, and 40 women with severe preeclampsia. The groups were matched in terms of maternal and gestational age and body mass index. Serum ghrelin levels were measured via enzyme immunoassay.

Results: Serum ghrelin levels were significantly higher in women with mild and severe preeclampsia than in healthy controls (p < 0.001). Although serum ghrelin levels were somewhat higher in the severe compared to the mild preeclampsia group, the difference was not statistically significant (p > 0.05). In the control group, no significant correlation was observed between ghrelin level and any other parameter, but in the preeclampsia group, serum ghrelin levels were negatively correlated with uterine artery Doppler index values and both systolic and diastolic blood pressure (all p-values < 0.05). Multivariate stepwise linear regression analysis revealed that systolic blood pressure (β = 0.493, p = 0.023) was independently associated with serum ghrelin level.

Conclusion: Elevated blood ghrelin levels were correlated with disease severity in pregnancies complicated by preeclampsia.

Abstract

Objectives: To investigate maternal serum ghrelin levels in pregnancies complicated by preeclampsia and to explore the relationship between ghrelin level and disease severity.

Materials and methods: This case-control study included 40 healthy pregnant women, 42 women with mild preeclampsia, and 40 women with severe preeclampsia. The groups were matched in terms of maternal and gestational age and body mass index. Serum ghrelin levels were measured via enzyme immunoassay.

Results: Serum ghrelin levels were significantly higher in women with mild and severe preeclampsia than in healthy controls (p < 0.001). Although serum ghrelin levels were somewhat higher in the severe compared to the mild preeclampsia group, the difference was not statistically significant (p > 0.05). In the control group, no significant correlation was observed between ghrelin level and any other parameter, but in the preeclampsia group, serum ghrelin levels were negatively correlated with uterine artery Doppler index values and both systolic and diastolic blood pressure (all p-values < 0.05). Multivariate stepwise linear regression analysis revealed that systolic blood pressure (β = 0.493, p = 0.023) was independently associated with serum ghrelin level.

Conclusion: Elevated blood ghrelin levels were correlated with disease severity in pregnancies complicated by preeclampsia.

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Keywords

ghrelin; pregnancy; preeclampsia

About this article
Title

Increased serum ghrelin in preeclampsia: is ghrelin a friend or a foe?

Journal

Ginekologia Polska

Issue

Vol 87, No 4 (2016)

Pages

277-282

Published online

2016-05-23

DOI

10.17772/gp/57852

Pubmed

27321099

Bibliographic record

Ginekol Pol 2016;87(4):277-282.

Keywords

ghrelin
pregnancy
preeclampsia

Authors

Onur Erol
Hamit Y. Ellidağ
Hülya Ayık
Gül A. Bülbül
Aysel U. Derbent
Sibel Kulaksızoğlu
Necat Yılmaz

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