open access
Pharmacotherapeutic aspects of drug transporters in the placenta
open access
Abstract
Drug treatment during pregnancy is often inevitable. The number of pregnant women in need of pharmacotherapy continues to grow, partly due to advanced diagnostic tests and partly due to advanced maternal age. Obviously, knowledge about the function of drug transporters in the placenta allows for a more accurate analysis of drug penetration (and other xenobiotics) through the placental barrier, and therefore safer pharmacotherapy. The paper provides information on the role of drug transporters in the pharmacotherapy of pregnancy-associated pathologies which require long-term treatment, e.g. cardiac arrhythmias, gestational diabetes, epilepsy, HIV infection, preeclampsia, and conditions which require the use of glucocorticoids.
Abstract
Drug treatment during pregnancy is often inevitable. The number of pregnant women in need of pharmacotherapy continues to grow, partly due to advanced diagnostic tests and partly due to advanced maternal age. Obviously, knowledge about the function of drug transporters in the placenta allows for a more accurate analysis of drug penetration (and other xenobiotics) through the placental barrier, and therefore safer pharmacotherapy. The paper provides information on the role of drug transporters in the pharmacotherapy of pregnancy-associated pathologies which require long-term treatment, e.g. cardiac arrhythmias, gestational diabetes, epilepsy, HIV infection, preeclampsia, and conditions which require the use of glucocorticoids.
Keywords
drug transporters; placenta; pharmacotherapy
About this articleTitle
Pharmacotherapeutic aspects of drug transporters in the placenta
Journal
Issue
Article type
Review paper
Pages
305-309
Published online
2016-05-23
Page views
1108
Article views/downloads
3709
DOI
10.17772/gp/61558
Pubmed
Bibliographic record
Ginekol Pol 2016;87(4):305-309.
Keywords
drug transporters
placenta
pharmacotherapy
Authors
Olga Motyl
Marek Droździk
